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Co-operative Effects of Thoracic X-ray Irradiation and N-nitrosobis(2-hydroxypropyl)amine Administration on Lung Tumorigenesis in Neonatal, Juvenile and Adult Wistar Rats.
https://repo.qst.go.jp/records/46501
https://repo.qst.go.jp/records/465014bd5cb98-c7c6-45d9-9f33-2b09566776ab
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-03-05 | |||||
タイトル | ||||||
タイトル | Co-operative Effects of Thoracic X-ray Irradiation and N-nitrosobis(2-hydroxypropyl)amine Administration on Lung Tumorigenesis in Neonatal, Juvenile and Adult Wistar Rats. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Iwata, Ken-ichi
× Iwata, Ken-ichi× Yamada, Yutaka× Nakata, Akifumi× Oghiso, Yoichi× Tani, Syusuke× Doi, Kazutaka× Morioka, Takamitsu× Blyth, Benjamin× Nishimura, Mayumi× Kakinuma, Shizuko× Shimada, Yoshiya× 岩田 健一× 山田 裕× 小木曽 洋一× 谷 修祐× 土居 主尚× 森岡 孝満× Blyth Benjamin× 西村 まゆみ× 柿沼 志津子× 島田 義也 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Childhood exposure to ionizing radiation (IR) and daily secondhand smoke increases the risk of developing lung cancer. Assessment of risks associated with childhood exposure to IR when combined with chemical carcinogens is of great importance. We studied the age dependence of the effect of combined exposure to IR and a chemical carcinogen on lung carcinogenesis. Female 1-, 5-, and 22-week-old Wistar rats were locally irradiated on the thorax with X-rays (3.18 Gy) and/or were injected intraperitoneally with N-nitrosobis(2-hydroxypropyl)amine (BHP) (1 g/kg body weight) 1 week after X-ray exposure or at 23 weeks of age. Rats were sacrificed at 90 weeks of age. We found that: (i) the incidence of lung tumors (both adenomas and adenocarcinomas) increased as a function of the age at X-ray exposure, whereas it decreased with age after BHP administration; (ii) combined exposure to X-rays at 5 or 22 weeks with BHP 1 week later promoted adenomas and adenocarcinomas; (iii) although a longer interval between the X-ray and BHP treatments reduced the combined effect, carcinogenic events of early-life irradiation at 1 or 5 weeks of age lasted into adulthood; (iv) most tumors originated from surfactant apoprotein A-positive alveolar type II cells; and (v), extracellular signal-regulated kinase pathway activation was observed in half the adenocarcinomas, regardless of the exposure schedule. Lung carcinogenesis following IR and BHP exposure is dependent on age-atexposure. Combined exposure to X-rays and BHP promoted lung tumorigenesis, especially malignant tumors, for all ages of irradiation. | |||||
書誌情報 |
Toxicology and Applied Pharmacology 巻 267, 号 3, p. 266-275, 発行日 2013-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-008X |