WEKO3
アイテム
{"_buckets": {"deposit": "8ebfb8a2-9b05-4c15-83de-096201a1db01"}, "_deposit": {"created_by": 1, "id": "46461", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46461"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046461", "sets": ["1"]}, "author_link": ["462925", "462934", "462926", "462932", "462928", "462927", "462931", "462929", "462923", "462924", "462933", "462930"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "1023", "bibliographicPageStart": "1019", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "Nuclear Medicine Communications"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: The aim of this study was to develop a method to predict a tracer\u0027s alpha-value in the human brain on the basis of animal data. The alpha-value is the ratio of the conversion rate and the back-diffusion rate (k3/k2) and is one of the critical kinetic features of the detection sensitivity of target molecule activity, such as enzyme activity, in the measurement of PET and single-photon emission computed tomography using an irreversible-type radiotracer.\nMethod: The alpha-value in the rat brain was estimated by a simultaneous assay of the tracer uptake and the target biochemical activity using N-[14C]-methylpiperidin-4-yl acetate ([14C]MP4A) and N-[14C]-methylpiperidin-4-yl propionate ([14C]MP4P) as test tracers, both of which are metabolic trapping tracers for measurement of brain acetylcholinesterase. The alpha-value in humans was then extrapolated from the alpha-value in rats by considering the differences between the species. The predicted human alpha-values were compared with those obtained from the kinetic analyses of human PET studies using [11C]MP4A and [11C]MP4P.\nResult: The alpha-values in the human brain cortex were predicted to be 0.51+/-0.1 for MP4A and 0.25+/-0.05 for MP4P. These results were close to values reported in other PET studies: 0.48+/-0.1 to 0.73+/-0.2 for MP4A and 0.15+/-0.04 to 0.18+/-0.04 for MP4P.\nConclusion: The alpha-value predicted by this method would be used for practical selection or development of irreversible-type radiotracers for human use.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1097/mnm.0b013e328356fbc3", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0143-3636", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ohya, Tomoyuki"}], "nameIdentifiers": [{"nameIdentifier": "462923", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "462924", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukumura, Toshimitsu"}], "nameIdentifiers": [{"nameIdentifier": "462925", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukushi, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "462926", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "462927", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Irie, Toshiaki"}], "nameIdentifiers": [{"nameIdentifier": "462928", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大矢 智幸", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "462929", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 明栄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "462930", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福村 利光", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "462931", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福士 清", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "462932", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菊池 達矢", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "462933", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "入江 俊章", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "462934", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluation"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46461", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-12-04"}, "publish_date": "2012-12-04", "publish_status": "0", "recid": "46461", "relation": {}, "relation_version_is_last": true, "title": ["A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluation"], "weko_shared_id": -1}
A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluation
https://repo.qst.go.jp/records/46461
https://repo.qst.go.jp/records/4646188003123-a621-4206-b70a-4d0b36c1227f
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2012-12-04 | |||||
タイトル | ||||||
タイトル | A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Ohya, Tomoyuki
× Ohya, Tomoyuki× Zhang, Ming-Rong× Fukumura, Toshimitsu× Fukushi, Kiyoshi× Kikuchi, Tatsuya× Irie, Toshiaki× 大矢 智幸× 張 明栄× 福村 利光× 福士 清× 菊池 達矢× 入江 俊章 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: The aim of this study was to develop a method to predict a tracer's alpha-value in the human brain on the basis of animal data. The alpha-value is the ratio of the conversion rate and the back-diffusion rate (k3/k2) and is one of the critical kinetic features of the detection sensitivity of target molecule activity, such as enzyme activity, in the measurement of PET and single-photon emission computed tomography using an irreversible-type radiotracer. Method: The alpha-value in the rat brain was estimated by a simultaneous assay of the tracer uptake and the target biochemical activity using N-[14C]-methylpiperidin-4-yl acetate ([14C]MP4A) and N-[14C]-methylpiperidin-4-yl propionate ([14C]MP4P) as test tracers, both of which are metabolic trapping tracers for measurement of brain acetylcholinesterase. The alpha-value in humans was then extrapolated from the alpha-value in rats by considering the differences between the species. The predicted human alpha-values were compared with those obtained from the kinetic analyses of human PET studies using [11C]MP4A and [11C]MP4P. Result: The alpha-values in the human brain cortex were predicted to be 0.51+/-0.1 for MP4A and 0.25+/-0.05 for MP4P. These results were close to values reported in other PET studies: 0.48+/-0.1 to 0.73+/-0.2 for MP4A and 0.15+/-0.04 to 0.18+/-0.04 for MP4P. Conclusion: The alpha-value predicted by this method would be used for practical selection or development of irreversible-type radiotracers for human use. |
|||||
書誌情報 |
Nuclear Medicine Communications 巻 33, 号 10, p. 1019-1023, 発行日 2012-09 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0143-3636 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/mnm.0b013e328356fbc3 |