WEKO3
アイテム
{"_buckets": {"deposit": "a5561c6d-6cdd-4ccf-aa3e-b54e06e0d6b9"}, "_deposit": {"created_by": 1, "id": "46233", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46233"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046233", "sets": ["1"]}, "author_link": ["460405", "460404"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "1000", "bibliographicPageStart": "991", "bibliographicVolumeNumber": "130", "bibliographic_titles": [{"bibliographic_title": "International Journal of Cancer"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy charged particles in space necessitate the study of the basic biological mechanisms associated with exposure to heavy ions. Since the most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses on DSBs induced by heavy ions and their repair processes. Compared with X- or gamma-rays, high linear energy transfer (LET) heavy ion radiation induces more complex DNA damage, categorized into DSBs and non-DSB oxidative clustered DNA lesions (OCDL). This complexity makes the DNA repair process more difficult, partially due to retarded enzymatic activities, leading to increased chromosome aberrations and cell death. In general, the repair process following heavy ion exposure is LET-dependent, but with non- homologous end- joining (NHEJ) defective cells, this trend is less emphasized. The variation in cell survival levels throughout the cell cycle is less prominent in cells exposed to high LET heavy ions as compared with low LET, but this mechanism has not been well-understood until recently. Involvement of several DSB repair proteins is suggested to underlie this interesting phenomenon. Recent improvements in radiation induced foci (RIF) studies combined with high LET heavy ion exposure could provide a useful opportunity for more in depth study of DSB repair processes. Accelerated heavy ions have become valuable tools to investigate the molecular mechanisms underlying repair of DNA DSBs, the most crucial form of DNA damage induced by radiation and various chemotherapeutic agents.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0020-7136", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Okayasu, Ryuichi"}], "nameIdentifiers": [{"nameIdentifier": "460404", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岡安 隆一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "460405", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Repair of DNA damage induced by accelerated heavy ions - A mini review", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Repair of DNA damage induced by accelerated heavy ions - A mini review"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46233", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-12-22"}, "publish_date": "2011-12-22", "publish_status": "0", "recid": "46233", "relation": {}, "relation_version_is_last": true, "title": ["Repair of DNA damage induced by accelerated heavy ions - A mini review"], "weko_shared_id": -1}
Repair of DNA damage induced by accelerated heavy ions - A mini review
https://repo.qst.go.jp/records/46233
https://repo.qst.go.jp/records/4623356e8b54c-b402-4b81-9a56-7e4c68786f6f
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-12-22 | |||||
タイトル | ||||||
タイトル | Repair of DNA damage induced by accelerated heavy ions - A mini review | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Okayasu, Ryuichi
× Okayasu, Ryuichi× 岡安 隆一 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy charged particles in space necessitate the study of the basic biological mechanisms associated with exposure to heavy ions. Since the most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses on DSBs induced by heavy ions and their repair processes. Compared with X- or gamma-rays, high linear energy transfer (LET) heavy ion radiation induces more complex DNA damage, categorized into DSBs and non-DSB oxidative clustered DNA lesions (OCDL). This complexity makes the DNA repair process more difficult, partially due to retarded enzymatic activities, leading to increased chromosome aberrations and cell death. In general, the repair process following heavy ion exposure is LET-dependent, but with non- homologous end- joining (NHEJ) defective cells, this trend is less emphasized. The variation in cell survival levels throughout the cell cycle is less prominent in cells exposed to high LET heavy ions as compared with low LET, but this mechanism has not been well-understood until recently. Involvement of several DSB repair proteins is suggested to underlie this interesting phenomenon. Recent improvements in radiation induced foci (RIF) studies combined with high LET heavy ion exposure could provide a useful opportunity for more in depth study of DSB repair processes. Accelerated heavy ions have become valuable tools to investigate the molecular mechanisms underlying repair of DNA DSBs, the most crucial form of DNA damage induced by radiation and various chemotherapeutic agents. | |||||
書誌情報 |
International Journal of Cancer 巻 130, 号 5, p. 991-1000, 発行日 2012-03 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0020-7136 |