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Stimulation of the Proliferation and Differentiation of Skin Cells by Ferrous Ferric Chloride from a Distance
https://repo.qst.go.jp/records/46119
https://repo.qst.go.jp/records/46119cf4769a1-649d-4ad9-93c6-53df62f33a00
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-06-27 | |||||
タイトル | ||||||
タイトル | Stimulation of the Proliferation and Differentiation of Skin Cells by Ferrous Ferric Chloride from a Distance | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× 廣部 知久 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ferrous ferric chloride (FFC) is a distinct form of aqueous iron composed of a complex of ferrous chloride and ferric chloride that participates in both oxidation and reduction reactions, and stimulates the proliferation and differentiation of mammalian keratinocytes, melanocytes, and fibroblasts. However, it is not known whether FFC can stimulate their proliferation and differentiation without being added into culture media or painted on the skin. This study aims to clarify whether FFC can stimulate their proliferation and differentiation from a distance without being added to culture media. In this study, FFC-containing skin lotions were painted under the culture dishes (1 mm away from cells) or on the top of the covers of 1 to 5 polystyrene culture dishes (1 to 5 cm away) and tested for their proliferation- and differentiation-stimulating effects. FFC lotions stimulated the proliferation and differentiation of human keratinocytes, melanocytes, and fibroblasts from a distance of 1 mm to 1 cm. However, FFC lotions failed to stimulate the proliferation and differentiation of melanocytes from distances of 2 to 5 cm. Results using Teflon covers were similar to those of polystyrene covers. Moreover, the effects of FFC lotions painted on the top of the Teflon covers were completely lost by lead disks. These results suggest that FFC can stimulate the proliferation and differentiation of skin cells from a distance of 1cm without being added into culture media through physical factors rather than chemical factors. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 34, 号 7, p. 987-995, 発行日 2011-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0918-6158 |