WEKO3
アイテム
Conversion of Ancestral Fibroblasts to Induced Pluripotent Stem Cells
https://repo.qst.go.jp/records/46108
https://repo.qst.go.jp/records/461083ee020b2-1039-4a41-9385-4e499479bdba
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-06-14 | |||||
| タイトル | ||||||
| タイトル | Conversion of Ancestral Fibroblasts to Induced Pluripotent Stem Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Araki, Ryoko
× Araki, Ryoko× Jintyou, Yuko× Fujimori, Yuko× Nakamura, Miki× Tamura, Chihiro× Ando, Syunsuke× Kasama, Yasuji× Abe, Masumi× 荒木 良子× 神長 祐子× 藤森 ゆう子× 中村 美樹× 安藤 俊輔× 笠間 康次× 安倍 真澄 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The emergence of induced pluripotent stem cells (iPSCs) from an ancestral somatic cell is one of the most important processes underlying their generation but the mechanism has yet to be identified. This is principally because these cells emerge at a low frequency, about 0.1% in the case of fibroblasts, and in a stochastic manner. In our current study, we succeeded in identifying ancestral fibroblasts and the subsequent processes leading to their conversion to iPSCs. The ancestral fibroblasts were found to divide several times in a morphologically symmetric manner, maintaining a fibroblastic shape, and then gradually transform into ES-like cells. Interestingly, this conversion occurred within 48 hours after gene introduction in most iPSC generations. This is the first report to directly observe a cell lineage conversion of somatic cells to stem cells and provides a critical new insight into the black box of iPSCs i.e. the first three days of their generation. | |||||
| 書誌情報 |
Stem Cells 巻 28, 号 2, p. 213-220, 発行日 2009-12 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1066-5099 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www3.interscience.wiley.com/journal/123215888/abstract?CRETRY=1&SRETRY=0 | |||||
| 関連名称 | http://www3.interscience.wiley.com/journal/123215888/abstract?CRETRY=1&SRETRY=0 | |||||
