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Subtypes of Cervical Adenosquamous Carcinomas Classified by EpCAM expression Related to Radiosensitivity
https://repo.qst.go.jp/records/46042
https://repo.qst.go.jp/records/4604296647ca7-f5a8-4020-b45a-55a901aaa3d5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-23 | |||||
| タイトル | ||||||
| タイトル | Subtypes of Cervical Adenosquamous Carcinomas Classified by EpCAM expression Related to Radiosensitivity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imadome, Kaori
× Imadome, Kaori× Iwakawa, Mayumi× Nakawatari, Miyako× Fujita, Hidetoshi× Kato, Shingo× Ohno, Tatsuya× Nakamura, Etsuko× Ohkubo, Yu× Tamaki, Tomoaki× Kiyohara, Hiroki× Imai, Takashi× 今留 香織× 岩川 眞由美× 中渡 美也子× 藤田 英俊× 加藤 眞吾× 大野 達也× 中村 悦子× 大久保 悠× 田巻 倫明× 清原 浩樹× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Adenosquamous carcinoma (ASC) is a relatively uncommon histological subtype of cervical cancer (CC). A point of controversy is the relative prognosis of ASC compared to squamous cell carcinoma (SCC). We hypothesized that ASC could be classified into two intrinsic molecular subtypes with different outcomes. We examined 143 biopsy samples of CC patients to identify a molecule for classification using microarray expression analysis and immunohistochemical analysis (IHA). We found specific expression profiles of candidate genes that distinguished two clusters. All adenocarcinoma (AC) patients were classified into one cluster, and most SCC patients fell into the other cluster. ASC patients were classified across the two clusters, which showed significantly different prognoses. The SCC-like expression signature comprised ANXA8, CK5, IFI16, and nectin-1; and the AC-like signature comprised EpCAM, and TMEM98. These signature-specific genes hypothetically indicated specific pathways by ontological analysis. The AC-like signature suggested an epithelial-mesenchymal transition and activated beta-catenin pathway, while the SCC-like signature suggested keratinocyte differentiation, HPV infection, and p53-mediated apoptosis. IHA revealed that positive expression of the most promising protein, EpCAM, was significantly associated with poor prognosis. In addition, the inhibition of EpCAM expression using siRNA significantly increased radiation-induced cell death in the cervical cell line, ME-180. In conclusion, we identified two possible ASC subtypes associated with different expression profiles and different prognoses. This work provides a novel set of genes that could be used as independent prognostic markers and therapy targets. | |||||
| 書誌情報 |
Cancer Biology & Therapy 巻 10, 号 10, p. 1019-1026, 発行日 2010-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1538-4047 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.4161/cbt.10.10.13249 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.landesbioscience.com/journals/cbt/article/13249/ | |||||
| 関連名称 | http://www.landesbioscience.com/journals/cbt/article/13249/ | |||||
