WEKO3
アイテム
{"_buckets": {"deposit": "b7e363da-cd81-4716-9bf2-85ca90353ddb"}, "_deposit": {"created_by": 1, "id": "45676", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "45676"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00045676", "sets": ["1"]}, "author_link": ["453923", "453924", "453918", "453925", "453922", "453921", "453920", "453919"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "22", "bibliographicPageEnd": "7288", "bibliographicPageStart": "7284", "bibliographicVolumeNumber": "52", "bibliographic_titles": [{"bibliographic_title": "Journal of Medicinal Chemistry"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "6-Bromo-7-[11C]methylpurine is reported to react with glutathione via glutathione S-transferases in the brain and to be converted into a substrate for multidrug resistance-associated protein 1 (MRP1), an efflux pump. The compound with a rapid conversion rate allows quantitative assessment of MRP1 function, but this rate is probably susceptible to interspecies differences. Hence, for application to different species, including humans, it is necessary to adjust the conversion rate by modifying the chemical structure. We therefore designed 6-halo-9-(or 7)-[ 14C]methylpurine (halogen: F, Cl, Br, or I), and evaluated them in vitro with respect to enzymatic reactivity with glutathione using brain homogenates from the mouse, rat, or monkey. There was a marked difference in reactivity between these species. Changes in the position of the methyl group and halogen on N-methyl-6-halopurine provided various compounds possessing wide-ranging reactivity with glutathione. In conclusion, the adjustment of reactivity of 6-bromo-7-[11C]methylpurine may allow assessment of MRP1 function in the brain in various species.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-2623", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Okamura, Toshimitsu"}], "nameIdentifiers": [{"nameIdentifier": "453918", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "453919", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukushi, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "453920", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Irie, Toshiaki"}], "nameIdentifiers": [{"nameIdentifier": "453921", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岡村 敏充", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "453922", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菊池 達矢", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "453923", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福士 清", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "453924", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "入江 俊章", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "453925", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Reactivity of 6-Halopurine Analogs with Glutathione as a Radiotracer for Assessing Function of Multidrug Resistance-Associated Protein 1", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Reactivity of 6-Halopurine Analogs with Glutathione as a Radiotracer for Assessing Function of Multidrug Resistance-Associated Protein 1"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/45676", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-11-30"}, "publish_date": "2009-11-30", "publish_status": "0", "recid": "45676", "relation": {}, "relation_version_is_last": true, "title": ["Reactivity of 6-Halopurine Analogs with Glutathione as a Radiotracer for Assessing Function of Multidrug Resistance-Associated Protein 1"], "weko_shared_id": -1}
Reactivity of 6-Halopurine Analogs with Glutathione as a Radiotracer for Assessing Function of Multidrug Resistance-Associated Protein 1
https://repo.qst.go.jp/records/45676
https://repo.qst.go.jp/records/456769cc4f288-8c7e-42e9-97a4-fcca9d62743d
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-11-30 | |||||
タイトル | ||||||
タイトル | Reactivity of 6-Halopurine Analogs with Glutathione as a Radiotracer for Assessing Function of Multidrug Resistance-Associated Protein 1 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Okamura, Toshimitsu
× Okamura, Toshimitsu× Kikuchi, Tatsuya× Fukushi, Kiyoshi× Irie, Toshiaki× 岡村 敏充× 菊池 達矢× 福士 清× 入江 俊章 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 6-Bromo-7-[11C]methylpurine is reported to react with glutathione via glutathione S-transferases in the brain and to be converted into a substrate for multidrug resistance-associated protein 1 (MRP1), an efflux pump. The compound with a rapid conversion rate allows quantitative assessment of MRP1 function, but this rate is probably susceptible to interspecies differences. Hence, for application to different species, including humans, it is necessary to adjust the conversion rate by modifying the chemical structure. We therefore designed 6-halo-9-(or 7)-[ 14C]methylpurine (halogen: F, Cl, Br, or I), and evaluated them in vitro with respect to enzymatic reactivity with glutathione using brain homogenates from the mouse, rat, or monkey. There was a marked difference in reactivity between these species. Changes in the position of the methyl group and halogen on N-methyl-6-halopurine provided various compounds possessing wide-ranging reactivity with glutathione. In conclusion, the adjustment of reactivity of 6-bromo-7-[11C]methylpurine may allow assessment of MRP1 function in the brain in various species. | |||||
書誌情報 |
Journal of Medicinal Chemistry 巻 52, 号 22, p. 7284-7288, 発行日 2009-11 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-2623 |