WEKO3
アイテム
CD44 and Bak expression in IL-6 or TNF-alpha gene knockout mice after whole lung irradiation
https://repo.qst.go.jp/records/45243
https://repo.qst.go.jp/records/452433e12d21f-6ee9-4305-8024-8c730f6d3ab8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-08-14 | |||||
| タイトル | ||||||
| タイトル | CD44 and Bak expression in IL-6 or TNF-alpha gene knockout mice after whole lung irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakai, Minako
× Sakai, Minako× Iwakawa, Mayumi× Iwakura, Youichirou× Oota, Toshie× Tsujii, Hirohiko× Imai, Takashi× 酒井 美奈子× 岩川 眞由美× 太田 敏江× 辻井 博彦× 今井 高志 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To understand the molecular mechanisms that underlie radiation pneumonitis, we examined whether knockout of the TNF or the IL-6 gene could give mice an inherent resistance to radiation in the acute phase of alveolar damage after thoracic irradiation. The temporal expression of inflammation (CD44) and apoptosis (Bak) markers in lung after thoracic irradiation was measured to determine the degree of alveolar damage. At 4 weeks post-irradiation (10 Gy), small inflammatory foci were observed in all mice, but there were no obvious histological differences between control (C57BL/6JSlc), TNF-alpha knockout (TNF KO), and IL-6 knockout (IL-6 KO) mice. However, immunohistochemical analysis of CD44 and Bak expression over a time course of 2 weeks highlighted significant differences between the three groups. C57BL/6JSlc and TNF KO mice had increased numbers of both CD44-positive and Bak-positive cells after irradiation, while the IL-6 KO mice showed stable levels of CD44 and Bak. In conclusion, the radioresistant status of IL-6 KO mice in the acute phase of alveolar damage after irradiation suggested an important role for IL-6 in radiation pneumonitis. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 49, 号 4, p. 409-416, 発行日 2008-07 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
