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Patients were treated with a combination of\nexternal beam irradiation and high-dose rate intracavitary irradiation.\n Cisplatin was given once a week for five weeks concurrently with the\nexternal beam irradiation. CRT was divided into low-dose CRT group\n(cisplatin, 20-30 mg/m2, n=16) and high-dose CRT group (cisplatin, 35-40\nmg/m2, n=14). Toxicities were evaluated before, every week up to 7\nweeks during the cycle, and 12 weeks after initial irradiation,\naccording to the National Cancer Institute Common Toxicity Criteria.\nResults: In the high-dose CRT group, anorexia during the first 5 weeks,\nleukopenia after 5 weeks, and weight loss at 6 weeks were significantly\nhigher than those in the RT alone group. In the low-dose CRT group,\nanorexia at 2 weeks, leukopenia after 5 weeks, and weight loss between 3\nand 4 weeks were significantly higher than those in the RT alone group\nbut the levels of toxicities were lower than those in the high-dose CRT\ngroup. There was no significant difference in the pattern of diarrhea\nbetween the RT alone and high-dose CRT groups, and it was significantly\nlower in the low-dose CRT group compared with RT alone.\nConclusion: These data can help us to understand when patients are\nlikely to develop maximal toxicities and to manage them with optimal timing.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0090-8258", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ohno, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "444538", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "444539", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakatuki, Masaru"}], "nameIdentifiers": [{"nameIdentifier": "444540", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Noda, Shinei"}], "nameIdentifiers": [{"nameIdentifier": "444541", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murakami, Chiemi"}], "nameIdentifiers": [{"nameIdentifier": "444542", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Misako"}], "nameIdentifiers": [{"nameIdentifier": "444543", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujii, Hirohiko"}], "nameIdentifiers": [{"nameIdentifier": "444544", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大野 達也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "444545", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "加藤 眞吾", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "444546", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "若月 優", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "444547", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "野田 真永", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "444548", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "村上 ちゑみ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "444549", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中村 美佐子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "444550", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "辻井 博彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "444551", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin:comparison with radiation therapy alone", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin:comparison with radiation therapy alone"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/44769", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-01-15"}, "publish_date": "2007-01-15", "publish_status": "0", "recid": "44769", "relation": {}, "relation_version_is_last": true, "title": ["Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin:comparison with radiation therapy alone"], "weko_shared_id": -1}
Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin:comparison with radiation therapy alone
https://repo.qst.go.jp/records/44769
https://repo.qst.go.jp/records/4476951f14750-d154-4968-bb49-d67bb7dfb159
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-01-15 | |||||
タイトル | ||||||
タイトル | Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin:comparison with radiation therapy alone | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Ohno, Tatsuya
× Ohno, Tatsuya× Kato, Shingo× Wakatuki, Masaru× Noda, Shinei× Murakami, Chiemi× Nakamura, Misako× Tsujii, Hirohiko× 大野 達也× 加藤 眞吾× 若月 優× 野田 真永× 村上 ちゑみ× 中村 美佐子× 辻井 博彦 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Abstract Objective: To investigate the temporal patterns of anorexia, diarrhea, weight loss, and leukopenia in chemoradiation therapy (CRT) for cervical cancer compared with radiation therapy (RT) alone. Methods: Thirty-eight patients receiving RT alone and 30 patients receiving CRT were studied. Patients were treated with a combination of external beam irradiation and high-dose rate intracavitary irradiation. Cisplatin was given once a week for five weeks concurrently with the external beam irradiation. CRT was divided into low-dose CRT group (cisplatin, 20-30 mg/m2, n=16) and high-dose CRT group (cisplatin, 35-40 mg/m2, n=14). Toxicities were evaluated before, every week up to 7 weeks during the cycle, and 12 weeks after initial irradiation, according to the National Cancer Institute Common Toxicity Criteria. Results: In the high-dose CRT group, anorexia during the first 5 weeks, leukopenia after 5 weeks, and weight loss at 6 weeks were significantly higher than those in the RT alone group. In the low-dose CRT group, anorexia at 2 weeks, leukopenia after 5 weeks, and weight loss between 3 and 4 weeks were significantly higher than those in the RT alone group but the levels of toxicities were lower than those in the high-dose CRT group. There was no significant difference in the pattern of diarrhea between the RT alone and high-dose CRT groups, and it was significantly lower in the low-dose CRT group compared with RT alone. Conclusion: These data can help us to understand when patients are likely to develop maximal toxicities and to manage them with optimal timing. |
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書誌情報 |
Gynecologic Oncology 巻 103, 号 1, p. 94-99, 発行日 2006-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0090-8258 |