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No age-related changes in human benzodiazepine receptor binding measured by PET with [11C]Ro 15-4513.
https://repo.qst.go.jp/records/44466
https://repo.qst.go.jp/records/44466c72269fb-313c-45e7-a211-7b480e62b255
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-12 | |||||
| タイトル | ||||||
| タイトル | No age-related changes in human benzodiazepine receptor binding measured by PET with [11C]Ro 15-4513. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suhara, Tetsuya
× Suhara, Tetsuya× Inoue, Osamu× Kobayashi, Kaoru× Suzuki, Kazutoshi× Tateno, Yukio× et.al× 須原 哲也× 井上 修× 鈴木 和年× 舘野 之男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of age on the binding of [11C]Ro 15-4513, a partial inverse agonist of the central benzodiazepine receptor, were studied. Sixteen healthy male volunteers (21-78 years old) participated. Regional radioactivity in the brain was followed for 45 min by positron emission tomography after a bolus injection of [11C]Ro 15-4513. Similar tracer kinetics were observed in both young and old subjects. For the quantification of receptor binding in vivo, a compartment model, in which radioactivity in the pons was used as an input function, was applied. There were no significant changes in the binding potentials with age (P > 0.1) in ten brain regions. These observations delineate an interesting difference between central benzodiazepine (BZ) receptors and other neurotransmitter receptors in the human brain measured by PET that have been shown to have a reduction with age. | |||||
| 書誌情報 |
Neuroscience Letters 巻 159, p. 207-210, 発行日 1993-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0304-3940 | |||||
