WEKO3
アイテム
{"_buckets": {"deposit": "c374297b-1bc7-430e-9011-e4cd770a4d6e"}, "_deposit": {"created_by": 1, "id": "43490", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "43490"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00043490", "sets": ["1"]}, "author_link": ["432487", "432493", "432499", "432492", "432491", "432495", "432488", "432497", "432498", "432496", "432494", "432490", "432489"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "1528", "bibliographicPageStart": "1525", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{"bibliographic_title": "Oncology Reports"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We investigated the effects of the farnesyl transferase inhibitor (FTI) manumycin and the MEK inhibitor PD98059 on growth of human pancreatic cancer, with mutant (SUIT2) or wild-type (BxPC-3) K-ras, xenografted into nude mice. Tumor growth was not reduced by either of the agents at a dose of 3 mg/kg without irradiation. Growth of SUIT2 irradiated at 15 Gy or 30 Gy was reduced by manumycin and PD98059: at 15 Gy, tumor volume doubling time (TVDT) increased from 18.6+/-3.8 to 36.3+/-14.2 days with PD98059 (p\u003c0.05); at 30 Gy, TVDT increased from 32.8+/-6.8 to 70.5+/-10.5 days and 70.7+/-1.5 days, respectively. Manumycin tended to reduce growth of BxPC-3, but the difference in TVDT was not statistically significant. PD98059 significantly increased the TVDT of BxPC-3 at 30 Gy from 34.4+/-18 to 62.6+/-9.8 at 30 Gy. The present results suggest that Ras signaling pathways are potential targets for manipulation of radiosensitivity, and that induction of an alternative pathway may enhance radiosensitivity of pancreatic cancer.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1021-335X", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsui, Yoshifumi"}], "nameIdentifiers": [{"nameIdentifier": "432487", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gotou, Miyako"}], "nameIdentifiers": [{"nameIdentifier": "432488", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwakawa, Mayumi"}], "nameIdentifiers": [{"nameIdentifier": "432489", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asano, Takehide"}], "nameIdentifiers": [{"nameIdentifier": "432490", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanmochi, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "432491", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imai, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "432492", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ochiai, Takenori"}], "nameIdentifiers": [{"nameIdentifier": "432493", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松井 芳文", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "432494", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中渡 美也子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "432495", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岩川 眞由美", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "432496", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "浅野 武秀", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "432497", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今井 高志", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "432498", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "落合 武徳", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "432499", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/43490", "pubdate": {"attribute_name": "公開日", "attribute_value": "2004-10-04"}, "publish_date": "2004-10-04", "publish_status": "0", "recid": "43490", "relation": {}, "relation_version_is_last": true, "title": ["Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor"], "weko_shared_id": -1}
Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor
https://repo.qst.go.jp/records/43490
https://repo.qst.go.jp/records/4349093b6b9ba-c328-444c-8e43-652f73b03cf8
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2004-10-04 | |||||
タイトル | ||||||
タイトル | Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Matsui, Yoshifumi
× Matsui, Yoshifumi× Gotou, Miyako× Iwakawa, Mayumi× Asano, Takehide× Kanmochi, Takashi× Imai, Takashi× Ochiai, Takenori× 松井 芳文× 中渡 美也子× 岩川 眞由美× 浅野 武秀× 今井 高志× 落合 武徳 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the effects of the farnesyl transferase inhibitor (FTI) manumycin and the MEK inhibitor PD98059 on growth of human pancreatic cancer, with mutant (SUIT2) or wild-type (BxPC-3) K-ras, xenografted into nude mice. Tumor growth was not reduced by either of the agents at a dose of 3 mg/kg without irradiation. Growth of SUIT2 irradiated at 15 Gy or 30 Gy was reduced by manumycin and PD98059: at 15 Gy, tumor volume doubling time (TVDT) increased from 18.6+/-3.8 to 36.3+/-14.2 days with PD98059 (p<0.05); at 30 Gy, TVDT increased from 32.8+/-6.8 to 70.5+/-10.5 days and 70.7+/-1.5 days, respectively. Manumycin tended to reduce growth of BxPC-3, but the difference in TVDT was not statistically significant. PD98059 significantly increased the TVDT of BxPC-3 at 30 Gy from 34.4+/-18 to 62.6+/-9.8 at 30 Gy. The present results suggest that Ras signaling pathways are potential targets for manipulation of radiosensitivity, and that induction of an alternative pathway may enhance radiosensitivity of pancreatic cancer. | |||||
書誌情報 |
Oncology Reports 巻 10, p. 1525-1528, 発行日 2003 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1021-335X |