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Induction of Micronuclei in a Rat Alveolar Epithelial Cell Line by Alpha Particle Irradiation
https://repo.qst.go.jp/records/43028
https://repo.qst.go.jp/records/430282a36fa13-f248-4f0e-8a05-0e1bfe5019ef
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-01-08 | |||||
| タイトル | ||||||
| タイトル | Induction of Micronuclei in a Rat Alveolar Epithelial Cell Line by Alpha Particle Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Yutaka
× Yamada, Yutaka× Oghiso, Yoichi× Enomoto, Hiroko× Ishigure, Nobuhito× 山田 裕× 小木曽 洋一× 榎本 宏子× 石榑 信人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dose-response relationships for the induction of micronuclei were characterised in the rat alveolar epithelial cell line (SV40T2) exposed to either alpha particles (241Am: 3.2 MeV, 128 keV.um-1, 0.093 Gy.min-1 at the cell-Mylar interface) or X rays (200 kVp, 1 Gy.min-1). The frequency of micronucleus formation was 1.6-3.0% for unirradiated subjects but increased for irradiated ones in a dose-dependent manner. A linear relationship between the dose and the micronucleus formation was observed until 1 Gy for alpha particles and 4 Gy for X rays. The linear slope for alpha particles was 28.5% per Gy and the relative biological effectiveness was 4.3 as calculated from the slopes. The slope for alpha particles was dependent on the energy of the alpha particles. These results indicate that the micronucleus assay is available for biodosimetry of alpha particle irradiation in the rat alveolar epithelial cells, although consideration should be given to the range of the linearity and the LET of alpha particles. | |||||
| 書誌情報 |
Radiation Protection Dosimetry 巻 99, p. 219-221, 発行日 2002 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0144-8420 | |||||
