http://swrc.ontoware.org/ontology#Article
ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM
en
Sato Tatsuhiko
Watanabe Ritsuko
Kase Yuki
Tsuruoka Chizuru
Suzuki Masao
Furusawa Yoshiya
Niita Koji
It is considered that the linear energy transfer (LET) may not be the ideal index for expressing the relative biological effective- ness (RBE) of cell killing for heavy-ion irradiation, as the ion-species dependencies have clearly been observed in the relation between LET and RBE derived from cell-survival fraction data. The previously measured survival fractions of four cell lines irra- diated by various ion species, employing the saturation-corrected dose-mean lineal energy, y*, instead of LET as the index of the RBE were therefore re-analysed. In the analysis, the initial slopes of the survival fractions, the so-called a-parameter in the linear-quadratic model, were plotted as a function of y*, which was calculated by the microdosimetric kinetic (MK) model implemented in the Particle and Heavy Ion Transport code System. It was found from the analysis that the ion-species depen- dencies observed in the relations between a and LET disappeared from those between a and y*, and their relations can be well reproduced by a simple equation derived from the MK model. These results clearly indicate the suitability of y* to be used in the estimation of the RBE of cell killing for heavy-ion irradiations, which is of great importance in the treatment planning of charged-particle therapy.
Radiation Protection Dosimetry
143
2/4
491-496
2010-12
0144-8420
10.1093/rpd/ncq484