量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Astatine-211 is one of the promising alpha-emitting radionuclides for the targeted alpha therapy (TAT), internal radiotherapy using alpha-emitting radioisotopes. At-211 is basically produced by irradiating He beams with 28–29 MeV to a bismuth (Bi) target. Irradiations with high beam current (µA order) are necessary to produce At-211 for preclinical and clinical studies because they require its radioactivity on the order of subGBq to GBq. Low melting point of Bi (273.1°C) often causes melting of the Bi during irradiation with high beam current. The aim of this study is therefore to optimize irradiation condition without observing Bi melting.
Evaluation of the Cooling Effect by He Gas for the Production of At-211 with a Bi plate
