量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Unirradiated liver volume (ULV) preservation rate is an important factor associated with radiation-induced liverdisease (RILD) in patients with hepatocellular carcinoma (HCC) undergoing proton beam therapy (PBT). The
purpose of this study is to identify the predictors for ULV preservation and quantify the capacity of proton beamsin normal liver sparing during PBT. We reviewed planning data of 92 patients with single intrahepatic HCC tumors
undergoing PBT. The potential clinical and planning factors that may affect ULV preservation were involved in multiple linear regression forULVpreservation rate.The significant factorswere determined to be predictors and their
influences were quantified. The median ULV preservation rate was 62.08%. All the assessed clinical factors showed significant effects on ULV preservation rate: clinical target volume (CTV), P <0.001; portal vein tumor thrombosis
(PVTT), P = 0.010; left lobe tumor, P = 0.010. In contrast, none of the planning factors demonstrated significance.The coefficients of significant factors in multiple linear regression were 60.85 for intercept,−0.02 for CTV,−9.01 for
PVTT and 8.31 for left lobe tumors. The capacity of proton beams to spare normal liver tissue during PBT for HCC ismainly affected by clinical factors. The baseline of theULV preservation rate is 60.85%, decreasing 0.02% with each
milliliter of CTV increase and 9.01% for tumors with PVTT, and increasing 8.31% for tumors limited to the left lobe.Further clinical studies should be carried out to correlate our dosimetric findings with clinical outcomes.
Capacity of proton beams in preserving normal liver tissue during proton beam therapy for hepatocellular carcinoma
