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We aimed to investigate the feasibility and efficacy of carbon-ion re-irradiation for patients with\npancreatic cancer who experienced recurrence after initial C-ion RT.\nMaterials and methods: Twenty-one patients with recurrent pancreatic cancer who underwent repeat Cion\nRT between December 2010 and November 2016 at our institute were retrospectively evaluated. The\nsites of post-initial C-ion RT failure were in-field central in 16 patients (76.2%) and marginal in 5 (23.8%).\nThe median doses of initial and repeat C-ion RT were both 52.8 Gy (relative biological effectiveness\n[RBE]). Thirteen patients (61.9%) received concurrent chemotherapy with re-irradiation, while 11\n(52.4%) received adjuvant chemotherapy.\nResults: The median follow-up period after re-irradiation was 11 months. The 1-year local control,\nprogression-free survival, and overall survival rates were 53.5%, 24.5%, and 48.7%, respectively. Toxicity\ndata was obtained from the patients’ charts. Only 1 patient (4.8%) developed grade 3 acute toxicities\nand none developed grade 3 late toxicities. Univariate analysis indicated that patients who received\nadjuvant chemotherapy had significantly improved local control rates compared with those who did\nnot; the 1-year local control rates were 80.0% and 0.0%, respectively (P = 0.0469).\nConclusion: Repeating C-ion RT may be a reasonable option with tolerable toxicity for patients with\nrecurrent pancreatic cancers. Adjuvant chemotherapy appears to improve the local control rate. 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Efficacy and feasibility of re-irradiation using carbon ions for pancreatic cancer that recurs after carbon-ion radiotherapy
https://repo.qst.go.jp/records/81066
https://repo.qst.go.jp/records/81066f463f605-015e-4e0c-b903-5bd6df3902bb
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-20 | |||||
タイトル | ||||||
タイトル | Efficacy and feasibility of re-irradiation using carbon ions for pancreatic cancer that recurs after carbon-ion radiotherapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hagiwara, Yasuhito
× Hagiwara, Yasuhito× Yamada, Shigeru× Isozaki, Yuka× Takiyama, Hirotoshi× Shinoto, Makoto× Kawashiro, Shohei× Bhattacharyya, Tapesh× Nemoto, Kenji× Tsuji, Hiroshi× Yasuhito, Hagiwara× Shigeru, Yamada× Yuka, Isozaki× Hirotoshi, Takiyama× Makoto, Shinoto× Shohei, Kawashiro× Bhattacharyya, Tapesh× Kenji, Nemoto× Hiroshi, Tsuji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and purpose: Patients who receive carbon-ion radiotherapy (C-ion RT) for primary pancreatic cancer may experience locoregional recurrence; however, the treatment options for such patients are limited. We aimed to investigate the feasibility and efficacy of carbon-ion re-irradiation for patients with pancreatic cancer who experienced recurrence after initial C-ion RT. Materials and methods: Twenty-one patients with recurrent pancreatic cancer who underwent repeat Cion RT between December 2010 and November 2016 at our institute were retrospectively evaluated. The sites of post-initial C-ion RT failure were in-field central in 16 patients (76.2%) and marginal in 5 (23.8%). The median doses of initial and repeat C-ion RT were both 52.8 Gy (relative biological effectiveness [RBE]). Thirteen patients (61.9%) received concurrent chemotherapy with re-irradiation, while 11 (52.4%) received adjuvant chemotherapy. Results: The median follow-up period after re-irradiation was 11 months. The 1-year local control, progression-free survival, and overall survival rates were 53.5%, 24.5%, and 48.7%, respectively. Toxicity data was obtained from the patients’ charts. Only 1 patient (4.8%) developed grade 3 acute toxicities and none developed grade 3 late toxicities. Univariate analysis indicated that patients who received adjuvant chemotherapy had significantly improved local control rates compared with those who did not; the 1-year local control rates were 80.0% and 0.0%, respectively (P = 0.0469). Conclusion: Repeating C-ion RT may be a reasonable option with tolerable toxicity for patients with recurrent pancreatic cancers. Adjuvant chemotherapy appears to improve the local control rate. This is the first study to examine re-irradiation using C-ion for recurrent pancreatic cancer after initial C-ion RT. |
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書誌情報 |
Clinical and Translational Radiation Oncology 巻 26, p. 24-29, 発行日 2020-11 |
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出版者 | ||||||
出版者 | ELSEVIER | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2405-6308 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ctro.2020.10.007 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.ctro.2020.10.007 |