量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果(学会誌発表論文、学会発表、研究開発報告書、特許等)を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Micro-Slit X-Ray Irradiation Reveals Testicular Tissue-Sparing Effects: An Attempt at High-Precision Radiotherapy for Male Fertility Preservation
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The preservation of male fertility during or after radiotherapy has long been desired to improve the quality of life for cancer survivors during their reproductive years. To approach this clinical issue, we focused on the tissue-sparing effect (TSE) in the testes in response to microbeam radiotherapy (MRT). In this study, we used ex vivo testicular tissue cultures obtained from Acr-GFP transgenic mice and revealed, for the first time, the significant TSE of high-precision MRT for maintaining spermatogenesis using live-tissue fluorescence imaging. This suggests that MRT is a promising approach for preserving male fertility.