量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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The search for an accurate, reliable, early disease biomarker for Parkinson disease (PD) from an easily accessible source is a high priority.1 α-Synuclein (α-Syn) is a small protein largely present in the CNS at the presynaptic neuronal terminals. The cause of PD is not clear, but aggregation or posttranslational modifications of α-Syn are currently thought to be an essential link in the chain of events leading to PD.1,2 Lewy type α-Syn deposition is found not only in the CNS but also in the peripheral nervous system of multiple organs including the endocrine glands, skin, stomach, and colon in PD with rostral-caudal gradient within the gastrointestinal gract.1,3 α-Syn is normally released by neuronal cells and is present in CSF and plasma.
Systemic Synuclein Sampling Study toward a Parkinson disease biomarker
