量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果(学会誌発表論文、学会発表、研究開発報告書、特許等)を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
Thank you very much for using our website. On the 11th of March 2019, this site was moved from our own network server to the JAIRO Cloud network server. If you previously bookmarked this site, that bookmark will no longer work. We would be grateful if you could bookmark the website again. Thank you very much for your understanding and cooperation.
[Objective]
99mTc-GSA SPECT is performed for patients before and after carbon-ion radiotherapy (CIRT) for liver tumors in our hospital. It is essential to assess reduced liver reserve capacity and prediction of post-CIRT value before treatment. In this study, we evaluated the usefulness of the liver reserve capacity estimation using GSA SPECT and CT/MRI fusion images in patients before and after CIRT for liver tumors.
[Materials and Methods]
Eight patients who received 99mTc-GSA SPECT imaging before and 3 months after CIRT were enrolled in this investigation. After intravenous injection of 99mTc-GSA, dynamic and SPECT imaging was performed using a gamma camera. All acquired SPECT images were fused with CT or MRI images using fusion viewer software, followed by evaluation of liver reserve capacity by the maximal GSA removal rate (GSA-Rmax) and GSA-Rmax of the predicted residual liver after CIRT (GSA-RL) using multicompartment analysis. Then we assessed correlation between GSA-RL before CIRT and GSA-Rmax after CIRT to evaluate the usefulness of residual liver function estimation with 99mTc-GSA SPECT.
[Results]
GSA-Rmax before and after CIRT were 0.302±0.189 and 0.264±0.172, respectively. GSA-RL before CIRT was 0.266±0.174, which was estimated using GSA SPECT-CT/MRI fusion images before CIRT. There was a high correlation between GSA-RL before CIRT and GSA-Rmax after CIRT (r=0.93, p<0.001).
[Conclusion]GSA SPECT is useful for evaluating liver reserve capacity and the prediction of post-CIRT value in patients with liver tumors.