量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Simultaneous measurements of the molar radioactivity, radiochemical purity and chemical impurity in the [11C]choline injection using radio-HPLC with a corona-charged aerosol detector.
利用統計を見る
[11C]choline has a weak UV absorption chromophore, and it is challenging to detect less than 1 μg/mL choline using radio-HPLC-UV. In this study, we established an analytical procedure of [11C]choline using the radio- HPLC coupled with the corona-charged aerosol detector. As a result, we achieved more than 100 GBq/μmol (over 0.1 μg/mL of choline) of molar radioactivity at the end of synthesis, over 95% of radiochemical purity, and more than 0.1 μg/mL of 2-dimethyoaminoethanol as a chemical impurity.
Simultaneous measurements of the molar radioactivity, radiochemical purity and chemical impurity in the [11C]choline injection using radio-HPLC with a corona-charged aerosol detector.
