WEKO3
アイテム
{"_buckets": {"deposit": "22b674f0-971d-49b6-bba8-49868cd8e2e1"}, "_deposit": {"created_by": 1, "id": "79914", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "79914"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00079914", "sets": ["1"]}, "author_link": ["925857", "925858", "925865", "925851", "925855", "925850", "925860", "925864", "925853", "925856", "925862", "925859", "925863", "925861", "925854", "925852"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "8514", "bibliographicPageStart": "8508", "bibliographicVolumeNumber": "2020", "bibliographic_titles": [{"bibliographic_title": "ACS Omega"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Vascular endothelial growth factor receptors (VEGFRs) are well recognized as significant biomarkers of tumor angiogenesis. Herein, we have developed a first-of-its-kind peptide-based VEGFR positron emission tomography (PET) tracer. The novel [64Cu]VEGF125–136 peptide possessed satisfactory radio-characteristics and showed good specificity for the visualization of VEGFR in various mouse models, in which the tumor-specific radioactivity uptake was highly correlated to the VEGFR expression level. Moreover, the tracer showed high tumor uptake (ca. 5.89 %ID/g at 20 min postinjection in B16F10 mice) and excellent pharmacokinetics, achieving the maximum imaging quality within 1 h after injection. These features convey [64Cu]VEGF125–136 as a promising, clinically translatable PET tracer for the imaging of tumor angiogenesis.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ACS Publications"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1021/acsomega.9b03953", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178340/", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2470-1343", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kuan, Hu"}], "nameIdentifiers": [{"nameIdentifier": "925850", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shang, Jingjie"}], "nameIdentifiers": [{"nameIdentifier": "925851", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Xie, Lin"}], "nameIdentifiers": [{"nameIdentifier": "925852", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanyu, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "925853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding"}], "nameIdentifiers": [{"nameIdentifier": "925854", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yang, Zhimin"}], "nameIdentifiers": [{"nameIdentifier": "925855", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Xu, Hao"}], "nameIdentifiers": [{"nameIdentifier": "925856", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lu, Wang"}], "nameIdentifiers": [{"nameIdentifier": "925857", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "925858", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "925859", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lin, Xie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "925860", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masayuki, Hanyu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "925861", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "925862", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yang, Zhimin", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "925863", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lu, Wang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "925864", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "925865", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/79914", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-04-24"}, "publish_date": "2020-04-24", "publish_status": "0", "recid": "79914", "relation": {}, "relation_version_is_last": true, "title": ["PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide"], "weko_shared_id": -1}
PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide
https://repo.qst.go.jp/records/79914
https://repo.qst.go.jp/records/79914871ab41f-a221-4478-9e5c-0a66c5e28a9c
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-04-24 | |||||
タイトル | ||||||
タイトル | PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Kuan, Hu
× Kuan, Hu× Shang, Jingjie× Xie, Lin× Hanyu, Masayuki× Zhang, Yiding× Yang, Zhimin× Xu, Hao× Lu, Wang× Ming-Rong, Zhang× Kuan, Hu× Lin, Xie× Masayuki, Hanyu× Zhang, Yiding× Yang, Zhimin× Lu, Wang× Zhang, Ming-Rong |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Vascular endothelial growth factor receptors (VEGFRs) are well recognized as significant biomarkers of tumor angiogenesis. Herein, we have developed a first-of-its-kind peptide-based VEGFR positron emission tomography (PET) tracer. The novel [64Cu]VEGF125–136 peptide possessed satisfactory radio-characteristics and showed good specificity for the visualization of VEGFR in various mouse models, in which the tumor-specific radioactivity uptake was highly correlated to the VEGFR expression level. Moreover, the tracer showed high tumor uptake (ca. 5.89 %ID/g at 20 min postinjection in B16F10 mice) and excellent pharmacokinetics, achieving the maximum imaging quality within 1 h after injection. These features convey [64Cu]VEGF125–136 as a promising, clinically translatable PET tracer for the imaging of tumor angiogenesis. | |||||
書誌情報 |
ACS Omega 巻 2020, 号 5, p. 8508-8514, 発行日 2020-04 |
|||||
出版者 | ||||||
出版者 | ACS Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2470-1343 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1021/acsomega.9b03953 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178340/ |