WEKO3
アイテム
{"_buckets": {"deposit": "8e7a8fb2-8b7a-41aa-806f-1ea0ab8cef36"}, "_deposit": {"created_by": 1, "id": "79769", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "79769"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00079769", "sets": ["28"]}, "author_link": ["862203", "862210", "862202", "862201", "862204", "862199", "862193", "862200", "862194", "862189", "862191", "862196", "862197", "862206", "862208", "862207", "862198", "862190", "862195", "862205", "862209", "862192"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2019-07-24", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objectives: \nOur previous studies demonstrated that 18F-PM-PBB3 (18F-APN-1607) uptake may reflect characteristic distributions of tau pathologies in 4-repeat tauopathies including progressive supranuclear palsy (PSP). The present study aimed to investigate the association among 18F-PM-PBB3 uptake, neurodegenerative biomarker level, and clinical symptoms in PSP with Richardson syndrome (PSP-RS) patients.\nMethods: \n21 patients with probable PSP-RS underwent PET scans with 18F-PM-PBB3 and 11C-PiB for estimating regional tau and Aβ deposition. Plasma neurofilament light chain (NfL) levels were also checked as a neurodegenerative biomarker. Parametric 18F-PM-PBB3- and 11C-PiB- images were generated by voxel-based calculation of the standardized uptake value ratio (SUVR) to the cerebellar cortex. Three patients, who were diagnosed as amyloid-positive by visual assessment of 11C-PiB SUVR image, were excluded. Finally, the other 18 PiB-negative PSP-RS patients were included for further analyses. Regional 18F-PM-PBB3 SUVR was estimated in dentate, midbrain, subthalamus, striatum, pre- and post-central gyri in addition to PSP tau PET meta-ROI. We assessed Pearson’s correlation of regional 18F-PM-PBB3 SUVR with plasma NfL levels and motor severity assessed by PSP rating scale. \nResults: \nPlasma NfL levels showed positive correlation with 18F-PM-PBB3 SUVR in striatum, pre- and post-central gyri as well as PSP tau PET meta-ROI (r = 0.77, 0.98, 0.95, and 0.78; p \u003c 0.05, followed by Bonferroni correction), and a trend toward significance in midbrain and dentate (r = 0.68 and 0.51; p = 0.008 and 0.043, without multiple comparison). PSP rating scale score positively correlated with plasma NFL (r = 0.73; p \u003c 0.01, followed by Bonferroni correction), and there were trends towards significance between PSP rating scale and 18F-PM-PBB3 SUVR in midbrain and PSP tau PET meta-ROI (r = 0.66 and 0.65; p = 0.01 and 0.03, without multiple comparison).\nConclusions: \nAccumulations of PM-PBB3 may reflect neurotoxic tau pathologies in PSP-RS, in tight association with clinical symptoms.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要(会議名, 開催地, 会期, 主催者等)", "attribute_value_mlt": [{"subitem_description": "Human Amyloid Imaging 2020", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "862189", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuoka, Kiwamu"}], "nameIdentifiers": [{"nameIdentifier": "862190", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubota, Manabu"}], "nameIdentifiers": [{"nameIdentifier": "862191", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahata, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "862192", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takado, Yuhei"}], "nameIdentifiers": [{"nameIdentifier": "862193", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Chie"}], "nameIdentifiers": [{"nameIdentifier": "862194", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Maiko"}], "nameIdentifiers": [{"nameIdentifier": "862195", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko"}], "nameIdentifiers": [{"nameIdentifier": "862196", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Kazunori"}], "nameIdentifiers": [{"nameIdentifier": "862197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "862198", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "862199", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862200", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuoka, Kiwamu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862201", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubota, Manabu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862202", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahata, Keisuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takado, Yuhei", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862204", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Chie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862205", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Maiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862206", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862207", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Kazunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862208", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862209", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "862210", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "18F-PM-PBB3 (18F-APN-1607) uptake associates with plasma NfL level and motor disability in patients with progressive supranuclear palsy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "18F-PM-PBB3 (18F-APN-1607) uptake associates with plasma NfL level and motor disability in patients with progressive supranuclear palsy"}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/79769", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-04-01"}, "publish_date": "2020-04-01", "publish_status": "0", "recid": "79769", "relation": {}, "relation_version_is_last": true, "title": ["18F-PM-PBB3 (18F-APN-1607) uptake associates with plasma NfL level and motor disability in patients with progressive supranuclear palsy"], "weko_shared_id": -1}
18F-PM-PBB3 (18F-APN-1607) uptake associates with plasma NfL level and motor disability in patients with progressive supranuclear palsy
https://repo.qst.go.jp/records/79769
https://repo.qst.go.jp/records/79769dd565cf2-ffcb-4ecb-97d7-f6768edacc9e
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-04-01 | |||||
タイトル | ||||||
タイトル | 18F-PM-PBB3 (18F-APN-1607) uptake associates with plasma NfL level and motor disability in patients with progressive supranuclear palsy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Shimada, Hitoshi
× Shimada, Hitoshi× Matsuoka, Kiwamu× Kubota, Manabu× Takahata, Keisuke× Takado, Yuhei× Seki, Chie× Ono, Maiko× Sahara, Naruhiko× Kawamura, Kazunori× Ming-Rong, Zhang× Higuchi, Makoto× Shimada, Hitoshi× Matsuoka, Kiwamu× Kubota, Manabu× Takahata, Keisuke× Takado, Yuhei× Seki, Chie× Ono, Maiko× Sahara, Naruhiko× Kawamura, Kazunori× Ming-Rong, Zhang× Higuchi, Makoto |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives: Our previous studies demonstrated that 18F-PM-PBB3 (18F-APN-1607) uptake may reflect characteristic distributions of tau pathologies in 4-repeat tauopathies including progressive supranuclear palsy (PSP). The present study aimed to investigate the association among 18F-PM-PBB3 uptake, neurodegenerative biomarker level, and clinical symptoms in PSP with Richardson syndrome (PSP-RS) patients. Methods: 21 patients with probable PSP-RS underwent PET scans with 18F-PM-PBB3 and 11C-PiB for estimating regional tau and Aβ deposition. Plasma neurofilament light chain (NfL) levels were also checked as a neurodegenerative biomarker. Parametric 18F-PM-PBB3- and 11C-PiB- images were generated by voxel-based calculation of the standardized uptake value ratio (SUVR) to the cerebellar cortex. Three patients, who were diagnosed as amyloid-positive by visual assessment of 11C-PiB SUVR image, were excluded. Finally, the other 18 PiB-negative PSP-RS patients were included for further analyses. Regional 18F-PM-PBB3 SUVR was estimated in dentate, midbrain, subthalamus, striatum, pre- and post-central gyri in addition to PSP tau PET meta-ROI. We assessed Pearson’s correlation of regional 18F-PM-PBB3 SUVR with plasma NfL levels and motor severity assessed by PSP rating scale. Results: Plasma NfL levels showed positive correlation with 18F-PM-PBB3 SUVR in striatum, pre- and post-central gyri as well as PSP tau PET meta-ROI (r = 0.77, 0.98, 0.95, and 0.78; p < 0.05, followed by Bonferroni correction), and a trend toward significance in midbrain and dentate (r = 0.68 and 0.51; p = 0.008 and 0.043, without multiple comparison). PSP rating scale score positively correlated with plasma NFL (r = 0.73; p < 0.01, followed by Bonferroni correction), and there were trends towards significance between PSP rating scale and 18F-PM-PBB3 SUVR in midbrain and PSP tau PET meta-ROI (r = 0.66 and 0.65; p = 0.01 and 0.03, without multiple comparison). Conclusions: Accumulations of PM-PBB3 may reflect neurotoxic tau pathologies in PSP-RS, in tight association with clinical symptoms. |
|||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Human Amyloid Imaging 2020 | |||||
発表年月日 | ||||||
日付 | 2019-07-24 | |||||
日付タイプ | Issued |