WEKO3
アイテム
{"_buckets": {"deposit": "017ca2ad-1ed4-420f-b9d6-a0014e58ce79"}, "_deposit": {"created_by": 1, "id": "78239", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "78239"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00078239", "sets": ["28"]}, "author_link": ["818245", "818243", "818234", "818244", "818235", "818239", "818251", "818253", "818238", "818241", "818242", "818252", "818249", "818237", "818259", "818248", "818261", "818233", "818260", "818262", "818258", "818254", "818257", "818250", "818247", "818240", "818236", "818246", "818255", "818256"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2019-01-17", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Aim \nPET imaging with [18F]PM-PBB3 ([18F]APN-1607) has demonstrated the capability of this radioligand for high-contrast visualization of tau deposits in the brains of Alzheimer’s disease (AD) and diverse other neurodegenerative disorders. This study was aimed at determining an optimal time frame of a PET scan to obtain a reliable target-to-reference ratio of radioligand concentrations in comparison with analytical models with an arterial input function.\nMethods \nTen subjects consisting of 5 healthy controls (HCs) and 3 AD and 2 progressive supranuclear palsy (PSP) patients underwent dynamic PET scans over 150 or 180 minutes after intravenous injection of [18F]PM-PBB3. Serial arterial blood samples were withdrawn during the scan to determine a metabolite-corrected plasma input function. Regional time-activity curves were analyzed with 1- and 2-tissue compartment models (TCMs) and Logan’s graphical analysis (LGA). Time-stability of total distribution (VT) values was examined to estimate scan duration sufficient for determination of VT. Non-displaceable biding potential (BPND) of [18F]PM-PBB3 was calculated using VT obtained with LGA, and SUVR in a 20-minute frame beginning at different time points after radioligand injection was calculated. SUVR-1 values were then compared with BPND to determine an optimal scan frame. \nResults\nA peak [18F]PM-PBB3 SUV in the brain approximated 2.5 at \u003c 5 minutes, followed by rapid radioactivity washout. Radioligand retentions in the lateral temporal cortex of AD patients and midbrain of PSP patients were characteristically increased relative to HCs. Two-TCM better described the radioligand kinetics in target regions than 1-TCM. VT values obtained with LGA presented the highest time-stability, and SUVR-1 values at 90-110 min showed the highest correlation with BPND among different frames. \nConclusions\n[18F]PM-PBB3 kinetics showed reversible binding and could be described without radiometabolite compartments in the brain. Estimation of SUVR at 90-110 min can be employed as a simplified means to quantify radioligand retention with sufficient robustness. \n", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要(会議名, 開催地, 会期, 主催者等)", "attribute_value_mlt": [{"subitem_description": "13th Human Amyloid Imaging Conference", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Seki, Chie"}], "nameIdentifiers": [{"nameIdentifier": "818233", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tagai, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "818234", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "818235", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "818236", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "818237", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori"}], "nameIdentifiers": [{"nameIdentifier": "818238", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Maiko"}], "nameIdentifiers": [{"nameIdentifier": "818239", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahata, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "818240", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubota, Manabu"}], "nameIdentifiers": [{"nameIdentifier": "818241", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takado, Yuhei"}], "nameIdentifiers": [{"nameIdentifier": "818242", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Maki"}], "nameIdentifiers": [{"nameIdentifier": "818243", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "818244", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "818245", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "818246", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "818247", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Chie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818248", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tagai, Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818249", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818250", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818251", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818252", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818253", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Maiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818254", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahata, Keisuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818255", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubota, Manabu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818256", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takado, Yuhei", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818257", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Maki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818258", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Tatsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818259", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818260", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818261", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "818262", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects"}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/78239", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-12-25"}, "publish_date": "2019-12-25", "publish_status": "0", "recid": "78239", "relation": {}, "relation_version_is_last": true, "title": ["Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects"], "weko_shared_id": -1}
Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects
https://repo.qst.go.jp/records/78239
https://repo.qst.go.jp/records/78239428e5e8f-e484-498b-b994-35f2b4906324
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-12-25 | |||||
タイトル | ||||||
タイトル | Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Seki, Chie
× Seki, Chie× Tagai, Kenji× Shimada, Hitoshi× Kitamura, Soichiro× Kimura, Yasuyuki× Ichise, Masanori× Ono, Maiko× Takahata, Keisuke× Kubota, Manabu× Takado, Yuhei× Okada, Maki× Kikuchi, Tatsuya× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto× Seki, Chie× Tagai, Kenji× Shimada, Hitoshi× Kitamura, Soichiro× Kimura, Yasuyuki× Ichise, Masanori× Ono, Maiko× Takahata, Keisuke× Kubota, Manabu× Takado, Yuhei× Okada, Maki× Kikuchi, Tatsuya× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aim PET imaging with [18F]PM-PBB3 ([18F]APN-1607) has demonstrated the capability of this radioligand for high-contrast visualization of tau deposits in the brains of Alzheimer’s disease (AD) and diverse other neurodegenerative disorders. This study was aimed at determining an optimal time frame of a PET scan to obtain a reliable target-to-reference ratio of radioligand concentrations in comparison with analytical models with an arterial input function. Methods Ten subjects consisting of 5 healthy controls (HCs) and 3 AD and 2 progressive supranuclear palsy (PSP) patients underwent dynamic PET scans over 150 or 180 minutes after intravenous injection of [18F]PM-PBB3. Serial arterial blood samples were withdrawn during the scan to determine a metabolite-corrected plasma input function. Regional time-activity curves were analyzed with 1- and 2-tissue compartment models (TCMs) and Logan’s graphical analysis (LGA). Time-stability of total distribution (VT) values was examined to estimate scan duration sufficient for determination of VT. Non-displaceable biding potential (BPND) of [18F]PM-PBB3 was calculated using VT obtained with LGA, and SUVR in a 20-minute frame beginning at different time points after radioligand injection was calculated. SUVR-1 values were then compared with BPND to determine an optimal scan frame. Results A peak [18F]PM-PBB3 SUV in the brain approximated 2.5 at < 5 minutes, followed by rapid radioactivity washout. Radioligand retentions in the lateral temporal cortex of AD patients and midbrain of PSP patients were characteristically increased relative to HCs. Two-TCM better described the radioligand kinetics in target regions than 1-TCM. VT values obtained with LGA presented the highest time-stability, and SUVR-1 values at 90-110 min showed the highest correlation with BPND among different frames. Conclusions [18F]PM-PBB3 kinetics showed reversible binding and could be described without radiometabolite compartments in the brain. Estimation of SUVR at 90-110 min can be employed as a simplified means to quantify radioligand retention with sufficient robustness. |
|||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 13th Human Amyloid Imaging Conference | |||||
発表年月日 | ||||||
日付 | 2019-01-17 | |||||
日付タイプ | Issued |