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However, how LET contributes to a therapeutic effect is not clear. To assess whether there is an enhanced effect of high LET radiation on tumour control, we aimed to determine the impact of dose-averaged LET on local control (LC) of primary pancreatic tumours.\nMaterials and methods\nA retrospective analysis of 18 patients with primary pancreatic carcinomas treated with definitive C-ion RT with concurrent chemotherapy in 2013 was conducted. The dose of irradiation was 55.2 Gy (RBE). The relationship between dose-averaged LET and LC of primary tumours was evaluated.\nResults\nAll patients had histologically confirmed adenocarcinoma. The median follow-up duration was 22 months. The actuarial LC and overall survival (OS) at 18 months were 62.5% and 70.1%, respectively. There were no cases of grade ≥3 late toxicities observed. Local recurrences developed in four patients (22%), all of which were infield central recurrences. Although there were no significant differences in gross tumour volume (GTV) dose coverage, patients with higher minimum dose-averaged LET (LETmin) values within the GTV had better LC (dose-averaged LETmin ≥44 keV/microm; 18-months LC 100.0% vs 34.3%; p = 0.0366).\nConclusion\nDose-averaged LETmin within the GTV was significantly associated with LC of primary pancreatic cancers. Our data suggest that outcomes for patients with unresectable primary pancreatic cancers receiving C-ion RT can be improved by modulating the dose-averaged LET within the GTV.\n", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ELSEVIER"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.ctro.2019.11.002", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.sciencedirect.com/science/article/pii/S2405630819301090", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2405-6308", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hagiwara, Yasuhito"}], "nameIdentifiers": [{"nameIdentifier": "1001887", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bhattacharyya, Tapesh"}], "nameIdentifiers": [{"nameIdentifier": "1001888", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsufuji, Naruhiro"}], "nameIdentifiers": [{"nameIdentifier": "1001889", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Isozaki, Yuka"}], "nameIdentifiers": [{"nameIdentifier": "1001890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takiyama, Hirotoshi"}], "nameIdentifiers": [{"nameIdentifier": "1001891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nemoto, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "1001892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuji, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "1001893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "1001894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuhito, Hagiwara", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1001895", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bhattacharyya, Tapesh", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1001896", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naruhiro, Matsufuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1001897", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yuka, Isozaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1001898", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirotoshi, Takiyama", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1001899", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kenji, Nemoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1001900", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hiroshi, Tsuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1001901", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shigeru, Yamada", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1001902", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/78221", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-12-23"}, "publish_date": "2019-12-23", "publish_status": "0", "recid": "78221", "relation": {}, "relation_version_is_last": true, "title": ["Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer"], "weko_shared_id": -1}
Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer
https://repo.qst.go.jp/records/78221
https://repo.qst.go.jp/records/78221fe9c5a03-3ab5-4040-b09c-fe651bd98e00
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-12-23 | |||||
タイトル | ||||||
タイトル | Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hagiwara, Yasuhito
× Hagiwara, Yasuhito× Bhattacharyya, Tapesh× Matsufuji, Naruhiro× Isozaki, Yuka× Takiyama, Hirotoshi× Nemoto, Kenji× Tsuji, Hiroshi× Yamada, Shigeru× Yasuhito, Hagiwara× Bhattacharyya, Tapesh× Naruhiro, Matsufuji× Yuka, Isozaki× Hirotoshi, Takiyama× Kenji, Nemoto× Hiroshi, Tsuji× Shigeru, Yamada |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and purpose High linear energy transfer (LET) radiation carbon-ion radiotherapy (C-ion RT) is one of the most promising modalities for treating unresectable primary pancreatic cancers. However, how LET contributes to a therapeutic effect is not clear. To assess whether there is an enhanced effect of high LET radiation on tumour control, we aimed to determine the impact of dose-averaged LET on local control (LC) of primary pancreatic tumours. Materials and methods A retrospective analysis of 18 patients with primary pancreatic carcinomas treated with definitive C-ion RT with concurrent chemotherapy in 2013 was conducted. The dose of irradiation was 55.2 Gy (RBE). The relationship between dose-averaged LET and LC of primary tumours was evaluated. Results All patients had histologically confirmed adenocarcinoma. The median follow-up duration was 22 months. The actuarial LC and overall survival (OS) at 18 months were 62.5% and 70.1%, respectively. There were no cases of grade ≥3 late toxicities observed. Local recurrences developed in four patients (22%), all of which were infield central recurrences. Although there were no significant differences in gross tumour volume (GTV) dose coverage, patients with higher minimum dose-averaged LET (LETmin) values within the GTV had better LC (dose-averaged LETmin ≥44 keV/microm; 18-months LC 100.0% vs 34.3%; p = 0.0366). Conclusion Dose-averaged LETmin within the GTV was significantly associated with LC of primary pancreatic cancers. Our data suggest that outcomes for patients with unresectable primary pancreatic cancers receiving C-ion RT can be improved by modulating the dose-averaged LET within the GTV. |
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書誌情報 |
Clinical and Translational Radiation Oncology 巻 21, p. 19-24, 発行日 2020-03 |
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出版者 | ||||||
出版者 | ELSEVIER | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2405-6308 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ctro.2019.11.002 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2405630819301090 |