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Immuno-PET imaging for non-invasive assessment of cetuximab accumulation in non-small cell lung cancer
https://repo.qst.go.jp/records/77350
https://repo.qst.go.jp/records/77350350e8c26-56d3-4e37-bc6d-f686da277005
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-10-11 | |||||
タイトル | ||||||
タイトル | Immuno-PET imaging for non-invasive assessment of cetuximab accumulation in non-small cell lung cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
山口, 藍子(群馬大学)
× 山口, 藍子(群馬大学)× Arifudin, Achmad(群馬大学)× 花岡, 宏史(群馬大学)× Yusri, Dwi Heryanto(群馬大学)× Anu, Bhattarai(群馬大学)× Ratianto(群馬大学)× Erdene, Khongorzul(群馬大学)× Rini, Shintawati(群馬大学)× Adhipatria, Kartamihardja(群馬大学)× 金井, 彩香(群馬大学)× 須郷, 由美× 石岡, 典子× 樋口, 徹也(群馬大学)× 対馬, 義人(群馬大学)× Yumi, Sugo× Noriko, Ishioka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study aimed to investigate the potential of radiolabeled cetuximab as a non-invasive tool to predict cetuximab accumulation in NSCLC tumor xenografts with varying EGFR expression levels. Strong correlations were found between 64Cu-DOTA-cetuximab tumor uptake with EGFR expression level. PET imaging with 64Cu-DOTA-cetuximab allowed clear visualization of tumors. Our findings suggest that this immuno-PET imaging can be clinically translated as a tool to predict cetuximab accumulation in NSCLC cancer patients prior to cetuximab therapy. | |||||
書誌情報 |
BMC Cancer 巻 19, 号 1, 発行日 2019-10 |
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出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1471-2407 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s12885-019-6238-4 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1186/s12885-019-6238-4 |