WEKO3
アイテム
{"_buckets": {"deposit": "4bf51012-ea09-4252-85d0-f75bce6553e8"}, "_deposit": {"created_by": 1, "id": "77343", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "77343"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00077343", "sets": ["29"]}, "author_link": ["799515", "799504", "799509", "799506", "799511", "799512", "799513", "799516", "799502", "799514", "799505", "799503", "799501", "799507", "799508", "799510"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2019-11-02", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: Metabotropic glutamate receptor subtype 1 (mGluR1) regulates glutamate (Glu) excitotoxicity in CNS. Here, we aimed to monitor mGluR1 in rat with excess Glu release. \nMethod: The rat, which intraperitoneally transplanted an Alzet osmotic pump containing N-acetyl-L-cysteine (NAC) solution, was used for this study. Extracellular Glu concentrations (EGc) were measured by microdialysis. PET assessments with [11C]ITDM, a selective radioligand for mGluR1, were conducted at several time points after the transplantation. \nResults: EGc in the day 1 (D1) of both groups increased compared to the pre-experiments. Following, EGc of NAC subjects kept rising until the D7. Similarly, PET study with [11C]ITDM showed retaining BPND with high level in the D7 of NAC subjects compared to the control subjects.\nConclusion: [11C]ITDM-BPND is upregulated depending on increase of EGc.\n", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要(会議名, 開催地, 会期, 主催者等)", "attribute_value_mlt": [{"subitem_description": "第59回日本核医学会学術総会", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "山崎, 友照"}], "nameIdentifiers": [{"nameIdentifier": "799501", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岡田, 真希"}], "nameIdentifiers": [{"nameIdentifier": "799502", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森, 若菜"}], "nameIdentifiers": [{"nameIdentifier": "799503", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張, 一鼎"}], "nameIdentifiers": [{"nameIdentifier": "799504", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "脇坂, 秀克"}], "nameIdentifiers": [{"nameIdentifier": "799505", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小川, 政直"}], "nameIdentifiers": [{"nameIdentifier": "799506", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤永, 雅之"}], "nameIdentifiers": [{"nameIdentifier": "799507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張, 明栄"}], "nameIdentifiers": [{"nameIdentifier": "799508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamasaki, Tomoteru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "799509", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Maki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "799510", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Wakana", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "799511", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "799512", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakizaka, Hidekatsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "799513", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogawa, Masanao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "799514", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujinaga, Masayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "799515", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "799516", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "Small-animal PET study: excess glutamate release upregulates mGluR1 availability", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Small-animal PET study: excess glutamate release upregulates mGluR1 availability"}]}, "item_type_id": "10005", "owner": "1", "path": ["29"], "permalink_uri": "https://repo.qst.go.jp/records/77343", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-11-07"}, "publish_date": "2019-11-07", "publish_status": "0", "recid": "77343", "relation": {}, "relation_version_is_last": true, "title": ["Small-animal PET study: excess glutamate release upregulates mGluR1 availability"], "weko_shared_id": -1}
Small-animal PET study: excess glutamate release upregulates mGluR1 availability
https://repo.qst.go.jp/records/77343
https://repo.qst.go.jp/records/773432295e342-ea9c-473b-9201-6b464145a67e
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-11-07 | |||||
タイトル | ||||||
タイトル | Small-animal PET study: excess glutamate release upregulates mGluR1 availability | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
山崎, 友照
× 山崎, 友照× 岡田, 真希× 森, 若菜× 張, 一鼎× 脇坂, 秀克× 小川, 政直× 藤永, 雅之× 張, 明栄× Yamasaki, Tomoteru× Okada, Maki× Mori, Wakana× Zhang, Yiding× Wakizaka, Hidekatsu× Ogawa, Masanao× Fujinaga, Masayuki× Ming-Rong, Zhang |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Metabotropic glutamate receptor subtype 1 (mGluR1) regulates glutamate (Glu) excitotoxicity in CNS. Here, we aimed to monitor mGluR1 in rat with excess Glu release. Method: The rat, which intraperitoneally transplanted an Alzet osmotic pump containing N-acetyl-L-cysteine (NAC) solution, was used for this study. Extracellular Glu concentrations (EGc) were measured by microdialysis. PET assessments with [11C]ITDM, a selective radioligand for mGluR1, were conducted at several time points after the transplantation. Results: EGc in the day 1 (D1) of both groups increased compared to the pre-experiments. Following, EGc of NAC subjects kept rising until the D7. Similarly, PET study with [11C]ITDM showed retaining BPND with high level in the D7 of NAC subjects compared to the control subjects. Conclusion: [11C]ITDM-BPND is upregulated depending on increase of EGc. |
|||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第59回日本核医学会学術総会 | |||||
発表年月日 | ||||||
日付 | 2019-11-02 | |||||
日付タイプ | Issued |