doi:10.1074/jbc.RA119.008415

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量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。
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Permalink : http://id.nii.ac.jp/1657/00076047/

Tau isoform expression and phosphorylation in marmoset brains 利用統計を見る

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Govind Sharma Anni Huo Kimura Taeko Seiji Shiozawa Reona Kobayashi Sahara Naruhiko Minaka Ishibashi Shinsuke Ishigaki Taro Saito Kanae Ando Shigeo Murayama Masato Hasegawa Gen Sobue Hideyuki Okano Hisanaga Shin-ichi
抄録	Tau is a microtubule-associated protein expressed in neuronal axons. Hyperphosphorylated tau is a major component of neurofibrillary tangles, a pathological hallmark of Alzheimer’s disease (AD). Hyperphosphorylated tau aggregates are also found in many neurodegenerative diseases, collectively referred to as “tauopathies,” and tau mutations are associated with familiar frontotemporal lobar degeneration (FTLD). Previous studies have generated transgenic mice with mutant tau as tauopathy models, but non-human primates, which are more similar to humans, may be a better model to study tauopathies. For example, the common marmoset is poised as a nonhuman primate model for investigating the etiology of age-related neurodegenerative diseases. However, no biochemical studies of tau have been conducted in marmoset brains. Here, we investigated several important aspects of tau, including expression of different tau isoforms and its phosphorylation status, in the marmoset brain. We found that marmoset tau does not possess the “primate unique motif” in its N-terminal domain. We also discovered that the tau isoform expression pattern in marmosets is more similar to that of mice than of humans, with adult marmoset brains expressing only four-repeat tau isoforms as in adult mice but unlike in adult human brains. Of note, tau in brains of marmoset newborns was phosphorylated at several sites associated with AD pathology. However, in adult marmoset brains, much of this phosphorylation was lost, except for Ser-202 and Ser-404 phosphorylation. These results reveal key features of tau expression and phosphorylation in the marmoset brain, a potentially useful non-human primate model of neurodegenerative diseases.
雑誌名	Journal of Biological Chemistry
巻	294
号	30
ページ	11433 - 11444
発行年	2019-06
出版者	ASBMB Publications
ISSN	0021-9258
PubMed番号	31171723
DOI	10.1074/jbc.RA119.008415
関連サイト	http://www.jbc.org/content/294/30/11433.long
著者版フラグ	none