量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Radiation damage to normal tissues is one of the most serious concerns in radiation therapy, and the tolerance dose of the normal tissues limits the therapeutic dose to the patients. p53 is well known as a transcription factor closely associated with radiation-induced cell death. We recently demonstrated the protective effects of several p53-regulating agents against low-LET X- or γ-ray-induced damage. Although it was reported that high-LET heavy ion radiation (> 85 keV/μm) could cause p53-independent cell death in some cancer cell lines, whether there is any radioprotective effect of the p53-regulating agents against the high-LET radiation injury in vivo is still unclear. In the present study we verified and confirmed the efficacy of these agents on bone marrow and intestinal damages induced by high-LET carbon-ion irradiation in mice. Vanadate dramatically improved 60-day survival rate in mice treated with total-body carbon-ion irradiation, indicating its effective protection of the hematopoietic system from radiation injury. 5CHQ slightly increased the survival rate after abdominal irradiation, suggesting the moderate relief of the intestinal damage. More detailed investigation is currently in progress to clarify the mechanisms involved in protecting the mice from high-LET radiation.
細胞死制御剤による重粒子放射線防護効果のマウス個体レベルでの検討
