量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
Thank you very much for using our website. On the 11th of March 2019, this site was moved from our own network server to the JAIRO Cloud network server. If you previously bookmarked this site, that bookmark will no longer work. We would be grateful if you could bookmark the website again. Thank you very much for your understanding and cooperation.
[Objective]
Choroidal melanoma is the most common primary ocular malignant tumor. I-123 IMP SPECT imaging was reported to be useful diagnostic imaging tool, however the diagnostic values in terms of assessment of fused image with CT/MRI and the semi-quantitative evaluation of the IMP-SPECT are still left to be discussed.
[Materials and Methods]
Among patients who visited our institution for carbon-ion radiotherapy, ten patients who received I-123 IMP SPECT imaging were enrolled in this investigation. Fifteen min and 24 hours after intravenous injection of the radiotracer, SPECT imaging was performed using a gamma camera (E.CAM, Canon Medical, Tokyo, Japan). All acquired SPECT images were fused with CT or MRI images using a fusion viewer software (AZE-Hayabusa, AZE, Japan). ROIs of the tumor, contralateral normal choroidal tissue and normal soft tissue referring to CT or MRI image were analyzed, followed by semi-quantitative evaluation was assessed using non-parametric Wilcoxon rank sum test.
[Results]
All tumors were visualized clearly in the 24h-SPECT image than those in 15min-SPECT image. The uptake index (UI) of the tumor: (tumor count) / (normal soft tissue count) and the contralateral normal choroidal tissue: (normal choroidal tissue count) / (normal soft tissue count) were 3.16+/-0.97 and 1.35+/-0.17, respectively (p < 0.001). The tumor-to-normal tissue ratios was 7.78+/-5.10.
[Conclusion]
I-123 IMP SPECT imaging performed 24h after injection of the radiotracer and fusion-image-analysis with CT or MRI were useful for detection of the choroidal melanoma. Also semi-quantitative evaluation using the fused images using tumor-UI and T/N ratio were considered to be valuable imaging techniques for diagnosis of the choroidal melanoma.
Assessment of SPECT-CT fusion images and semi-quantitative evaluation of I-123 IMP SPECT in patients with ocular choroidal melanoma.
