WEKO3
アイテム
{"_buckets": {"deposit": "b5bba6e1-17a0-4d38-88e6-363868224d20"}, "_deposit": {"created_by": 1, "id": "75493", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "75493"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00075493", "sets": ["1"]}, "author_link": ["894390", "894392", "894398", "894389", "894394", "894396", "894397", "894395", "894393", "894391"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "301", "bibliographicPageStart": "294", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "Biotechnology \u0026 Biotechnological Equipment "}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We used a mitochondria-penetrating nitroxide, mito-TEMPO, as a contrast probe for imaging of kidney dysfunction in mice, based on the redox-imbalance and oxidative stress in the renal tissues. Kidney dysfunction was triggered by hypercholesterolemia. The mice were divided in three groups: (i) on normal diet (ND; control); (ii) on cholesterol diet (CD); (iii) on cholesterol plus cholestyramine diet (CC). CD mice showed increased plasma levels of total cholesterol and non-HDL-cholesterol, as well as increased serum levels of blood urea nitrogen, uric acid and creatinine, compared to ND mice. CC mice showed slightly increased plasma levels of total cholesterol and HDL-cholesterol, but not non-HDL-cholesterol, compared to ND mice. The serum levels of blood urea nitrogen, uric acid and creatinine in CC mice were equal to those in ND mice. The MRI signal of mito-TEMPO in the kidneys was characterized by: high intensity and long life-time in CD mice, indicating a high oxidative capacity of renal tissues; poor intensity and short life-time in ND mice, indicating a high reducing capacity of renal tissues; moderate intensity and relatively short life-time in CC mice, which shows the protective effect of lipid-lowering agents against oxidative damage. The data suggest that hypercholesterolemia induces redox-imbalance and oxidative stress in kidneys and this process could be visualized using MRI and mito-TEMPO as a redox-sensitive contrast substance.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Taylor \u0026 Francis"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1080/13102818.2019.1573153", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.tandfonline.com/doi/full/10.1080/13102818.2019.1573153", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1310-2818", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Lazarova, Dessislava"}], "nameIdentifiers": [{"nameIdentifier": "894389", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Sayaka"}], "nameIdentifiers": [{"nameIdentifier": "894390", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishii , Itsuko"}], "nameIdentifiers": [{"nameIdentifier": "894391", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zlateva , Genoveva"}], "nameIdentifiers": [{"nameIdentifier": "894392", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhelev , Zhivko"}], "nameIdentifiers": [{"nameIdentifier": "894393", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki, Ichio"}], "nameIdentifiers": [{"nameIdentifier": "894394", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bakalova, Rumiana"}], "nameIdentifiers": [{"nameIdentifier": "894395", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Sayaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "894396", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki, Ichio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "894397", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bakalova, Rumiana", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "894398", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/75493", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-03-27"}, "publish_date": "2019-03-27", "publish_status": "0", "recid": "75493", "relation": {}, "relation_version_is_last": true, "title": ["Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol"], "weko_shared_id": -1}
Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol
https://repo.qst.go.jp/records/75493
https://repo.qst.go.jp/records/75493ed85fe24-19ed-4b70-a6a8-404d21c26f5b
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-03-27 | |||||
タイトル | ||||||
タイトル | Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Lazarova, Dessislava
× Lazarova, Dessislava× Shibata, Sayaka× Ishii , Itsuko× Zlateva , Genoveva× Zhelev , Zhivko× Aoki, Ichio× Bakalova, Rumiana× Shibata, Sayaka× Aoki, Ichio× Bakalova, Rumiana |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We used a mitochondria-penetrating nitroxide, mito-TEMPO, as a contrast probe for imaging of kidney dysfunction in mice, based on the redox-imbalance and oxidative stress in the renal tissues. Kidney dysfunction was triggered by hypercholesterolemia. The mice were divided in three groups: (i) on normal diet (ND; control); (ii) on cholesterol diet (CD); (iii) on cholesterol plus cholestyramine diet (CC). CD mice showed increased plasma levels of total cholesterol and non-HDL-cholesterol, as well as increased serum levels of blood urea nitrogen, uric acid and creatinine, compared to ND mice. CC mice showed slightly increased plasma levels of total cholesterol and HDL-cholesterol, but not non-HDL-cholesterol, compared to ND mice. The serum levels of blood urea nitrogen, uric acid and creatinine in CC mice were equal to those in ND mice. The MRI signal of mito-TEMPO in the kidneys was characterized by: high intensity and long life-time in CD mice, indicating a high oxidative capacity of renal tissues; poor intensity and short life-time in ND mice, indicating a high reducing capacity of renal tissues; moderate intensity and relatively short life-time in CC mice, which shows the protective effect of lipid-lowering agents against oxidative damage. The data suggest that hypercholesterolemia induces redox-imbalance and oxidative stress in kidneys and this process could be visualized using MRI and mito-TEMPO as a redox-sensitive contrast substance. | |||||
書誌情報 |
Biotechnology & Biotechnological Equipment 巻 33, 号 1, p. 294-301, 発行日 2019-02 |
|||||
出版者 | ||||||
出版者 | Taylor & Francis | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1310-2818 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1080/13102818.2019.1573153 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.tandfonline.com/doi/full/10.1080/13102818.2019.1573153 |