量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Even when only a limited number of cells in a population are irradiated with spatially limited ionizing radiation, such as microbeam, unexposed cells could also be affected by receiving certain intercellular signals from the irradiated cells. This "bystander effects" has been intensively studied from the point of view of low-dose radiation risk. To investigate detailed mechanism of the unique non-targeting effects, we analyzed the characteristics of the bystander signaling among the cells using a mathematical model, which consists of several simple functions describing production of intercellular signal molecules, DNA damage induction, or cell death. We evaluated these functions by fitting simulation results to experimental ones in a previous report. Linear and non-linear characteristics of bystander signaling were revealed by analysis of typical radiation response of bystander effects.
Computational analysis of bystander signaling in cellular population irradiated with microbeam
