量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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[11C]PBB3 binding capacity [cm3] as a total volume of voxels whose binding potential values (BP*ND) above a threshold in a target region. Amyloid β depositions were evaluated by estimating standardized uptake value ratio (SUVR) for [11C]PiB between the entire cerebral cortex and cerebellar cortex. A cortical [11C]PiB SUVR above 1.21 was considered to be high uptake4. All PET scans were performed with a Bigograph mCT flow system (Siemens Healthcare, Erlangen, Germany). Psychiatric symptoms were evaluated by clinical scales and neuropsychological tests.
RESULTS: TBI patients showed higher [11C]PBB3 binding capacities in the neocortical gray and white matter but not in the subcortical gray or subcortical white matter compared to controls. TBI patients with late-onset psychiatric symptoms had higher [11C]PBB3 binding capacities in the white matter compared to those without late-onset psychiatric symptoms. Among TBI patients, [11C]PBB3 binding capacity in the cortical and subcortical white matter showed positive correlation with severity of psychosis as assessed by Brief Psychiatric Rating Scale (BPRS). Among TBI patients and normal control subjects, only one single-severe TBI patients was [11C]PiB positive (cortical [11C]PiB PET SUVR: 1.32).
Discussion/Conclusion: Our results provide the in vivo evidence of distinctive distribution of tau neuropathology in TBI brains. Late-onset symptoms following TBI are associated with higher tau depositions in the cortical white matter, implicating physical injury-provoked axonal tau accumulations in the deteriorations of the brain functions.
会議概要（会議名, 開催地, 会期, 主催者等）
12nd International Symposium of Functional Neuroreceptor Mapping of the Living Brain (NRM2018)
Association between tau neuropathology in TBI patients and late-onset psychiatric symptoms: A PET study
