量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Background: Heart Rhythm Society (HRS) consensus statement recommends that patients with biopsy-proven extra cardiac sarcoidosis (extra-CS) should be screened for CS with a 12-lead electrocardiogram (ECG) and echocardiogram. There are lack of studies investigating prevalence of CS in patients with normal ECG and echocardiogram. We sought to investigate prevalence and explore characteristics among these patient cohorts. Methods: We included consecutive biopsy proven extra-CS patients with normal ECG and echocardiogram. All patients underwent FDG-PET and cardiac MRI for the evaluation of CS. The Japanese Ministry of Health and Welfare (JMHW) criteria 2015 were used as the standard for the diagnosis of CS. Results: Forty-five patients were included. Six patients of 45 (13%) were diagnosed wi th CS. Of the 6 patients with CS, 1 patient had multiple organ involvements (lung, skin, stomach, bone and heart), 3 patients had cardiac involvements in the remote area from the interventricular septum such as RV papillary muscle, inferior or lateral wall, 1 patient had small subendocardial lesions on the mid segments of the anteroseptal and inferior walls, and 1 had relatively low LVEF for his age.Conclusions: The prevalence of CS exceeds 10% even in extra-CS patients with normal ECG and echocardiogram. Physicians should keep in mind in such population.
Prevalence of cardiac involvement in patients with biopsy-proven extracardiac sarcoidosis and normal electrocardiogram and echocardiogram
