量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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We are developing high sensitivity dedicated brain PET, helmet PET, which has a spherically arranged detector unit and add-on detector unit for improving sensitivity at low cost. There are emerging demands for such dedicated brain PET imaging for early diagnosis of dementia, because several diagnostic tracers for Alzheimer’s disease have been developed. The hemispherical arrangement of the detector can improve the sensitivity for the brain region significantly. In addition, the add-on detector can significantly improve the sensitivity at the center, where the sensitivity without the add-on detector is still low as the same as the conventional cylindrical PET. For a proof-of-concept, we first developed the helmet-chin PET having the add-on detectors at chin position. Next, we developed the helmet-neck PET prototype because, in theory, the effect of the add-on detector is equivalent no matter its position. We evaluated basic performance of the prototypes and conducted healthy volunteer study with 18F-FDG. Sensitivity composition showed the helmet-neck PET had higher sensitivity for brain region because the neck detector can be placed closer than the chin detector which required safety margin in designing. The result showed that the helmet PET with add-on detector had promising performance for high-sensitivity and high-resolution brain imaging with reduced cost.
会議概要（会議名, 開催地, 会期, 主催者等）
1st QST International Symposium Quantum Life Science
Helmet PET enabling high sensitivity brain imaging toward early diagnosis of dementia
