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量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。
Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Permalink : http://id.nii.ac.jp/1657/00072257/

PET quantification of binding of a novel tau radioligand, 18F-AM-PBB3, in consideration of time-dependent changes in its plasma free fraction. 利用統計を見る

アイテムタイプ	会議発表用資料 / Presentation
言語	英語
著者	北村聡一郎木村泰之市瀬正則関千江島田斉篠遠仁久保田学高畑圭輔高堂裕平森口翔石井辰弥張明栄須原哲也樋口真人
抄録	Objectives A novel tau PET ligand, 18F-AM-PBB3, has been developed by structural modifications of 11C-PBB3. Time-activity curves (TACs) in the brain obtained by human PET indicated a good radioligand uptake after injection consistent with reversible binding kinetics. Plasma parent TAC showed an initial rapid rise followed by a decline, which then plateaued with no further decreases. We hypothesized that the plasma parent free fraction may not be constant but rather decrease with time, and therefore analyzed kinetics of 18F-AM-PBB3 with plasma input functions corrected for sequentially measured parent free fractions. \nMethods One Alzheimer’s disease (AD) and one healthy control (HC) subject underwent a dynamic PET scan, arterial blood sampling, and free fraction measurements after injection of 18F-AM-PBB3. We estimated two plasma input functions with and without free fraction corrections. One- and two-tissue compartment analyses (1TCM, 2TCM) were performed for both input functions to estimate binding potential (BPND) using cerebellar gray matter as reference. A reference tissue model (MRTMO) was also applied to estimate BPND without using blood data. We compared curve fitting and BPND values between these methods to evaluate the validity of the input correction for the plasma free fraction in compartment modeling. \nResults Plasma parent free fractions decreased over time (AD: 2.3%, HC:3.0% at 3 min and AD: 0.37, HC: 0.41% at 180 min). 2TCM produced a better fit to tissue TACs than did 1TCM with corrected input functions. Neither 1TCM nor 2TCM with uncorrected inputs described tissue TACs well. BPND values estimated by 2TCM with corrected inputs and MRTMO were in an excellent agreement. \nConclusions Plasma inputs corrected for free fractions, which decreased over time, allowed quantification of 18F-AM-PBB3 binding using 2TCM, and a good correlation was found between estimates by this method and more practical reference tissue model requiring no plasma data.
会議概要（会議名, 開催地, 会期, 主催者等）	Brain and Brain PET 2017
発表年月日	2017-04-02
著者版フラグ	none

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