量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Effects of prenatal low-dose irradiations of heavy ions on the embryonic development of melanocytes have not been well studied. The aim of this study is to investigate in detail the effects of low-dose heavy ions on the development of melanocytes in embryonic skin of mice. Pregnant females of C57BL/10J mice were irradiated whole-body at 9 days of gestation with a single acute dose of silicon, argon and iron ions in addition to gamma-rays, and the number of melanoblasts and melanocytes in the epidermis and hair bulbs of 18-day-old embryos was counted histochemically. Drastic decrease in the number of epidermal melanoblasts and melanocytes and hair bulb melanocytes was observed even in 0.1 Gy-treated embryos, and the number gradually decreased as dose increased. The decrease in the number of dorsal hair bulb melanocytes well correlated with the linear energy transfer of radiations tested, but not in the number of dorsal and ventral epidermal melanoblasts and melanocytes as well as ventral hair bulb melanocytes. Moreover, the effects of heavy ions on the ventral skin were greater than those on the dorsal skin especially in melanocyte numbers. These results suggest that the prenatal exposure to low-dose heavy ions possesses an inhibitory effect on the proliferation and differentiation of melanocytes with a greater effect on the ventral skin than on the dorsal skin.
Effects of Low-dose Heavy Ions on the Embryonic Development of Melanoblasts and Melanocytes in the Epidermis and Hair Bulb of Mice
