WEKO3
アイテム
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The whole pelvic dose was fixed at 36.0 gray equivalents (GyE). With regard to local boost, a dose-escalation study was planned with an initial dose of 26.4 GyE for 8 fractions and then gradually increased up to 38.4 GyE for 8 fractions by 2.4 or 3.6 GyE increments. At least 5 patients were treated at the same dose level, and dose escalation was performed after careful observation of acute normal tissue responses. Total dose to the cervical tumor was 62.4-74.4 GyE for 20 fractions. \nResults;\nBetween April 1998 and February 2010, 58 patients of locally advanced adenocarcinoma were treated with C-ion RT in this clinical trial. Median age was 59 years (range, 28-85 years). Twenty patients had stage IIB disease, 35 patients had stage IIIB disease, and 3 patients had stage IVA disease. Median tumor size was 5.5 cm (range, 3.0-11.8 cm). Histologically, 48 patients had adenocarcinoma and 10 patients had adenosquamous cell carcinoma. Twenty-seven patients had lymph node metastases in the pelvis. The median follow-up period for surviving and all patients were 44 and 31 months, respectively. Although 23 patients developed acute toxicity (G1-G3), all patients completed the scheduled therapy. Late toxicity was found in as many as 19 patients but toxicity observed was G1 or G2 except one: G1 toxicity was found 15 patients (24%): 12 patients for rectum/sigmoid, 4 for small intestine and 6 for bladder. G2 toxicity was detected 7 patients (12 %): 5 patients for bladder and 2 patients for small intestine. Only exception was G4 for rectal complication, which was surgically salvaged. Complete response rate and partial response rate for C-ion RT were 60.3% and 34.5%, respectively. Twenty-seven patients (46.6%) had local recurrence, and ten of which received salvage surgery. The 3-year local control rate and overall survival rate were 53.4% and 53.4% respectively. Thirty-six patients (62.1%) had distant metastases. The overall 3-year local control rate including salvage surgery was 62.9%.\nConclusions;\nCarbone ion radiotherapy is a safe and effective treatment for locally advanced adenocarcinoma of the uterine cervix.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要(会議名, 開催地, 会期, 主催者等)", "attribute_value_mlt": [{"subitem_description": "European Society for Therapeutic Radiology and Oncology 31(ESTRO31)", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Wakatuki, Masaru"}], "nameIdentifiers": [{"nameIdentifier": "694929", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "694930", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohno, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "694931", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Karasawa, Kumiko"}], "nameIdentifiers": [{"nameIdentifier": "694932", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ando, Ken"}], "nameIdentifiers": [{"nameIdentifier": "694933", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyohara, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "694934", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "694935", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamada, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "694936", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Syozu, Makio"}], "nameIdentifiers": [{"nameIdentifier": "694937", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "若月 優", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "694938", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "加藤 眞吾", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "694939", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "唐澤 久美子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "694940", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安藤 謙", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "694941", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鎌田 正", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "694942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "生水 真紀夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "694943", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix"}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/70743", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-05-16"}, "publish_date": "2012-05-16", "publish_status": "0", "recid": "70743", "relation": {}, "relation_version_is_last": true, "title": ["Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix"], "weko_shared_id": -1}
Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix
https://repo.qst.go.jp/records/70743
https://repo.qst.go.jp/records/70743cbd8e7a6-4a9d-47b7-8527-760859f9c154
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2012-05-16 | |||||
タイトル | ||||||
タイトル | Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Wakatuki, Masaru
× Wakatuki, Masaru× Kato, Shingo× Ohno, Tatsuya× Karasawa, Kumiko× Ando, Ken× Kiyohara, Hiroki× Nakano, Takashi× Kamada, Tadashi× Syozu, Makio× 若月 優× 加藤 眞吾× 唐澤 久美子× 安藤 謙× 鎌田 正× 生水 真紀夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose/Objective; To evaluate the toxicity and efficacy of carbon ion radiotherapy (C-ion RT) forlocally advanced adenocarcinoma and adenosquamous carcinoma of the uterine cervix by phase I/II clinical trials. Material/Methods; The treatment consisted of 12 fractions of whole pelvic irradiation, 8 fractions of extended local boost. The whole pelvic dose was fixed at 36.0 gray equivalents (GyE). With regard to local boost, a dose-escalation study was planned with an initial dose of 26.4 GyE for 8 fractions and then gradually increased up to 38.4 GyE for 8 fractions by 2.4 or 3.6 GyE increments. At least 5 patients were treated at the same dose level, and dose escalation was performed after careful observation of acute normal tissue responses. Total dose to the cervical tumor was 62.4-74.4 GyE for 20 fractions. Results; Between April 1998 and February 2010, 58 patients of locally advanced adenocarcinoma were treated with C-ion RT in this clinical trial. Median age was 59 years (range, 28-85 years). Twenty patients had stage IIB disease, 35 patients had stage IIIB disease, and 3 patients had stage IVA disease. Median tumor size was 5.5 cm (range, 3.0-11.8 cm). Histologically, 48 patients had adenocarcinoma and 10 patients had adenosquamous cell carcinoma. Twenty-seven patients had lymph node metastases in the pelvis. The median follow-up period for surviving and all patients were 44 and 31 months, respectively. Although 23 patients developed acute toxicity (G1-G3), all patients completed the scheduled therapy. Late toxicity was found in as many as 19 patients but toxicity observed was G1 or G2 except one: G1 toxicity was found 15 patients (24%): 12 patients for rectum/sigmoid, 4 for small intestine and 6 for bladder. G2 toxicity was detected 7 patients (12 %): 5 patients for bladder and 2 patients for small intestine. Only exception was G4 for rectal complication, which was surgically salvaged. Complete response rate and partial response rate for C-ion RT were 60.3% and 34.5%, respectively. Twenty-seven patients (46.6%) had local recurrence, and ten of which received salvage surgery. The 3-year local control rate and overall survival rate were 53.4% and 53.4% respectively. Thirty-six patients (62.1%) had distant metastases. The overall 3-year local control rate including salvage surgery was 62.9%. Conclusions; Carbone ion radiotherapy is a safe and effective treatment for locally advanced adenocarcinoma of the uterine cervix. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Society for Therapeutic Radiology and Oncology 31(ESTRO31) | |||||
発表年月日 | ||||||
日付 | 2012-05-13 | |||||
日付タイプ | Issued |