量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Introduction:Pediatric inflammatory bowel disease(PIBD) is considered to be a multifactorial disease with both genetic and acquired factors involved in its etiology. THe acquired factors include lifestyles and environmental factors of both patients in pediatric period and their mothers in perinatal period. Parental smoking, not breast-feeding(human milk substitite), mental atress, lack of sleeping time, low body activity, appendectomy, preterm delivery, and some genetic variants concerning pathways of immune responses such as CARD15/NOD2, DLG5, TLR4, OCTN1/2, MYO9B, IL23R, ATG16L, have reported to be possible risk factors for PIBD. However, to date, there has been no study analyzing these factors simultaneously and clarifying their confoundings. The present study tries to elucidate genetic and acquired risk factors for PIBD and their confounding.
Methods:PIBD cases and controls were recruited from affiliated hospital of the Japan workshop for pediatric inflammatory bowel disease. Saliva sample of patients for genotyping and self-administrated questionnaire for their motjers were obtained with written informed-consent.
Result and conclusion:This paper will report interim results of the study starting from 2011. The present study is expected to develop early and individualized measures to prevent PIBD, intervention for lifestyles and environmental factors of expectant mothers possessing genetic risk factors for baby's future PIBD manifestation. Future, the results may contribute to clarify new pathogenesis of PIBD manifestation and more useful disease classification.
A case-control study to detect genetic and acquired risk factors for pediatric inflammatory bowel disease
