量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Pregnancy-induced hypertention (PIH), major cause of maternal morbidity and mortality, is considered to be a multifactorial disease resulting from an interaction among several factors including endothelial injury. Tumor necrosis factor-alpha (TNF-A) fundamentally effects on the endothelial cells by several pathways, such as oxidant/anti-oxidant balances, changing patterns of prostaglandin production and expression of cell surface components. Some recent studies have reported that an association between a common variants in promoter region (G-308A) of the TNF-A gene and PIH in some racial population, however, it has been yet confirmed. In the present study, we genotyped and analyzed the variant and other genetic and environment risk factors in order to confirm the association in the Japanese subjects.
会議概要（会議名, 開催地, 会期, 主催者等）
THe 59th Annual Meeting of The American Society of Human Genetics
A common variant of tumor necrosis factor-alpha gene and pregnancy-induced hypertention in Japan
