量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Aim: To investigate the clinical value of FLT-PET in the evaluation of lung cancer patients treated with carbon-ion radiation therapy (CIRT). Materials & Methods: Eighteen consecutive patients (pts) with lung cancer who are going to be treated with CIRT received FLT-PET/CT before (18 pts) and 3 months after CIRT (13 pts). Fifty minutes after intravenous injection of approximately 296 MBq of FLT, PET/CT data were acquired. Maximal standardized uptake values (SUV) were measured and compared with short-term effect evaluated by the reduction of maximal tumor diameter measured by CT at 3 months post CIRT. Initial FLT uptake in the tumor was compared with the occurrence of local recurrence and/or metastasis. The study plan was approved by the Institutional Ethical Committee and informed consent was obtained from all patients before each FLT-PET examination. Results: Before CIRT, squamous cell carcinomas tended to show higher FLT uptake than adenocarcinomas did, although the difference was not statistically significant (3.70 +/- 1.88 versus 2.31 +/- 1.17, p=0.058). Three months after CIRT, both maximal diameter and maximal FLT-uptake showed significant reduction compared to those before CIRT (p=0.004 for maximal diameter and p=0.002 for SUV). There was a significant correlation between the reduction rate (RR) of FLT-uptake [(SUVpre - SUVpost)/SUVpre] and the reduction rate of maximum diameter [(Diameter-pre - Diameter-post)/Diameter-pre] (p=0.003). In 7 of 13 pts, CT showed the development of radiation pneumonitis (RP) 3 months after CIRT, and mild to weak FLT uptake was observed in the area of RP. Pts developing RP tended to show lower reduction rate of FLT-uptake than pts not developing RP (0.25 +/- 0.41 with RP versus 0.53 +/- 0.09 without RP, p=0.063). In 14 pts having more than 6-months follow-up period, 7 pts developed local recurrence and/or metastases, and pts having recurrence/metastases tended to show higher SUVpre, although not statistically significant (3.74 +/- 1.39 versus 2.81 +/- 0.82, p=0.116). Conclusion: Although the number of pts is limited and the follow up period is not long enough, the present preliminary data suggests the feasibility of FLT-PET in lung cancer patients being treated with CIRT. The presence of RP can modify the FLT uptake in the treated tumor and may cause underestimation of the CIRT effect. Although there is a possibility that higher tumor uptake of FLT before CIRT can be a predictor of recurrence/metastases, more cases are necessary to prove this.
会議概要（会議名, 開催地, 会期, 主催者等）
Annual Congress of the European Association of Nuclear Medicine 2008
FLT-PET for the Evaluation of Lung Cancer Patients Treated with Carbon-Ion Radiation Therapy: Initial Results
