量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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A radiation-induced adaptive response, which was judged as reduction of both fetal death and digital malformation, was demonstrated in fetal mice by priming low-dose radiation on E11 prior to a high-dose irradiation on E12. Suppression of the digital defects was correlated to the inhibition of radiation-induced apoptosis. The priming dose was mouse strain-related. Both Trp53 alleles were essential for induction of the adaptive response. Furthermore, existence of the dose-rate effect was verified for delivery of the priming dose. There was a high postnatal mortality in the offspring that survived from prenatal death. Postnatal retardation, alteration in adult behavior, and life span shortening were observed in the survivals. In addition, a significantly increased radiosensitivity to the killing effect was also observed in the postnatal survivals. These results indicate that radiation-induced adaptive response in fetal mice is due to a complex interplay between dose, dose rate and animal factors such as the strain, developmental stage, and gene background. Though the priming dose could rescue some mice from high dose irradiation, the survivals are not healthy as alterations in development, behavior and radiosensitivity were observed. This work was supported in part by the Budget for New Nuclear Crossover Research from the Ministry of education, Culture, Sports, Sciences and Technology, Japan.
Study on radiation-induced adaptive response in fetal mice.
