量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Clinically, soft feces and a decline of reproductive performance were observed in specific pathogen free C3H-scid mice in our SPF animal facility. Grossly, the ceca of these mice were smaller than those of normal mice and it's contents have decreased. Histopathologically, severe edema was observed in the cecal submucosa, and inflammatory cells such as neutrophils and mononuclear cells were infiltrated in the lamina propria and submucosa of the ceca and colon. Microbiologically, Clostridium difficile (C. difficile) were isolated from the cecal contents and toxin A was detected from the isolate, and not detected Salmonella spp., C. rodentium, P. aeruginosa, C. kutscheri, C. piliformis, mouse hepatitis virus by bacteriologically or serologically test. Colitis associated with C. difficile in gnotobiotic mice has been pathologically characterized by decreased cecal size, polymorphonuclear cell infiltration and edema of lamina propria in large intestine [Onderdonk et al]. And has reported that inflammatory edema of cecal submucosa occurred in mice monoassociated with moderately toxinogenic C. difficile strains [Vernet et al]. These pathological findings in this case resemble to those of mice described in these reports. From a cecal content in an affected mouse, C. difficile producing toxin A was isolated. Therefore, based on the pathological findings and the result of microbiological examination, our case was diagnosed as C. difficile-associated colitis in scid mice.
会議概要（会議名, 開催地, 会期, 主催者等）
The american college of veterinary pathologists 56th annual meeting
Colitis associated with Clostridium difficile in the specific pathogen free C3H-scid mice.
