量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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A Newly Constructed SPF Animal Facility, -Low Dose Radiation Effects Research Building-, in The National Institute of Radiological Science, Japan
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The Low Dose Radiation Effects Research Building was constructed in the National Institute of Radiological Sciences in March 2003 to clarify biological effects of low dose radiation by SPF animal experiments.
This building consists of five floors on the ground level and one floor under the ground level. The first floor is about 800 square meters and the total floor areas of this building are about 4,100 square meters. There are four mouse rooms keeping 11,000 mice, four rat rooms keeping 3,000 rats and two quarantine rooms for each rodent. One room and three rooms of each rodent are P2 level and P1 level, respectively. All animal racks are one way air flow type. Each anteroom has a safety cabinet for chemo-hazard. Large equipments for animal husbandry are two floor-loading type autoclaves, an ethylene oxide gas sterilizer, a cage wash-dry-machine, and an automatic drinking water maker. There are also a neutron irradiator, low dose-rate 137Cs gamma-ray irradiator and a high dose-rate 137Cs gamma-ray irradiator in the SPF animal area.
In November, 2004, mice and rats were started to keep. Total of four-hundred and twenty animals are quarantined when they were purchased from a commercial breeder for about eighteen months. They were free of Pseudomonas aeruginosa. Routine monthly microbiological monitoring for sentinel animals indicates that SPF status is maintained. In the monthly descend bacteria test, the number of bacteria at a room with one way air flow racks in this facility is one- twentieth at a room with open racks in another SPF animal facility in the NIRS.
A Newly Constructed SPF Animal Facility, -Low Dose Radiation Effects Research Building-, in The National Institute of Radiological Science, Japan
