量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Purpose:
There is an emerging demand for dedicated brain PET for the study and diagnosis of neurological disorders such as dementia. We have proposed a helmet PET geometry with add-on detector for high sensitivity, high resolution and low cost brain PET. Our first prototype had the add-on detector at chin position (helmet-chin PET). However, the gantry design gave oppressive feeling to the patient and moving part of chin detector was not convenient for the patient setup. We have shown by simulation that the add-on detectors covering the patient head is equivalently effective. In this study, we developed the helmet-neck PET for improving the convenience.
Methods and Materials:
We developed the helmet PET prototype using 54 four-layer depth-of-interaction detectors with 16×16×4 array of 2.8×2.8×7.5 mm3 Zr-doped GSO crystals. In the prototype, 47 detectors were arrangement in a hemisphere, and seven detectors were placed as an add-on detector. We compared helmet-chin PET and helmet-neck PET in terms of the effect of the add-on detector for increasing the sensitivity.
Results:
The sensitivity measured with a hemispherical phantom for the brain region was increased by 12% in the helmet-chin PET and by 19% in the helmet-neck PET compared with the geometry without add-on detector. This is because the arrangement of the detector at chin position required larger margin for designing gantry, in which detector position became farther than the case of neck position.
Conclusion:
The helmet-neck PET has promising performance for high sensitivity brain imaging and improved convenience for patient studies.
Development of the helmet-neck PET prototype for high sensitivity brain imaging
