量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Purpose: Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with Malignant Melanoma in nasal cavity. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis and the prognosis in patients with Malignant Melanoma in nasal cavity.
Methods: Forty-six patients were prospectively studied by MET-positron emission tomography (PET) before and about 1 month after CIRT. The tumor MET uptake was measured with the semiquantitative tumor to normal tissue ratio (TNR). The tumor TNR and relevant clinical parameters were then evaluated by both univariate and multivariate analyses.
Results: The average TNRs before and after the treatment were 7.0 (+/-4.4) and 5.1 (+/-2.7), respectively, and significant differences were observed between them.
In a univariate analysis, local recurrence was observed more frequently in the group with a higher TNR before the treatment than a lower TNR (cut-off value was 6.2), and the prognosis was poor in the group with a higher TNR before and after the treatment than a lower TNR (cut-off values were 4.4 and 7.4, respectively).
In a multivariate analysis, significant differences was observed for relationship between the TNR before the treatment and prognosis. No significant difference was observed for relationship between TNR after the treatment and the treatment results.
Conclusions: The determination of treatment effectiveness using TNR in CIRT for nasal cavity Malignant Melanoma is an independent factor for predicting prognosis. MET-PET is therefore considered to be useful for determining the treatment effectiveness in patients with nasal cavity Malignant Melanoma undergoing CIRT.
多変量解析による鼻腔悪性黒色腫の重粒子線治療効果予測因子の検討：11C-Methionine PETとその他基本因子
