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Purpose: To estimate the toxicity and efficacy of carbon ion radiotherapy for skull base and paracervical
tumors in clinical trials.
Patients and Methods: A phase I/II dose escalation study for skull base and paracervical tumors was initiated in
April 1997. The patients were treated with 16 fractions for 4 weeks with a total dose of 48.0, 52.8, 57.6, or
60.8Gy equivalents (GyE). In April of 2004, a phase II study was initiated with an irradiation schedule of
60.8GyE in 16 fractions over four weeks. There were 76 patients included in the analysis. Histologically, 44
patients had chordoma, 12 chondrosarcoma, 9 olfactory neuroblastoma, 7 malignant meningioma, 1 giant cell
tumor, and 1 had a neuroendocrine carcinoma. The patients were treated with a dose of 48.0 GyE (4 patients),
52.8 GyE (6 patients), 57.6 GyE (9 patients) or 60.8 GyE (57 patients).
Results: The follow-up periods ranged from 3 to 158 months, with a median period of 46 months. At the time
of the analysis, there was no evidence of any serious acute (Grade ≥4 ) or late (Grade ≥3) reactions. The 5-year
local control and overall survival rates for all patients were 88% and 82%, respectively. The 5-year local control
and overall survival rates for chordoma patients were 88% and 87%, respectively.
Conclusion: A carbon ion dose of 60.8GyE in 16 fractions was effective and safe for the treatment of skull
base and paracervical tumors.
会議概要（会議名, 開催地, 会期, 主催者等）
2nd NIRS-ETOILE Joint Symposium on Carbon Ion Therapy
Carbon Ion Radiotherapy for Skull Base and Paracervical Tumors
