量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Aim:To evaluate the changes in dopamine (DA) synthesis capacity before and after antipsychotic treatment in patients with schizophrenia.
Method:Twelve patients underwent positron emission tomography studies with [11C]DOPA before (baseline) and 1 day after treatment with antipsychotic drug, risperidone. DA synthesis capacity, ki, was determined for the striatum using a graphical plot analysis method and with the occipital cortex as a reference region.
Result:Patients showed no significant unidirectional change in DA synthesis capacity before and after risperidone administration; However, a significant negative correlation was observed between the baseline ki value and the change rate of ki before and after risperidone administration (r = -0.63, p = 0.029).
Conclusion:These findings might be indicative of a stabilizing effect of risperidone to the presynaptic DA function.
統合失調症における抗精神病薬前後でのドーパミン生成能の変化
