量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Glioblastoma (GBM) is one of the most common and the most malignant tumor occurring in the central nervous system. GBM is notorious for highly growth and invasive behavior and makes the surgical intervention ineffective. Recently, though there are many reports about the effectiveness of carbon ion therapy, little is known about effects of carbon ion therapy for GBM. In addition, the almost of GBM patients has not satisfied with treatment of the carbon ion alone for GBM.
Temozolomide (TMZ) is a cytotoxic alkylating agent which has shown an activity in the recurrent anaplastic glioma and GBM. Combining TMZ with radiotherapy followed by maintenance TMZ has been reported to improve outcome compared with radiation alone, and this treatment is currently considered as the standard treatment for GBM. Hence, in this study, we investigated the effectiveness of combining TMZ with carbon ion therapy for GBM.
重粒子線と化学療法の併用療法における脳正常組織および神経膠芽腫の放射線感受性の検討
