量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Purpose: To identify haplotypes of SNP markers associated with risk of adverse reactions after radiotherapy (RT).
Patients and Methods: DNA samples were collected from 153 cervical cancer patients, who underwent conventional RT. The ninety-two patients received no chemotherapy. A total of 1201 SNPs from 173 candidate genes for radiation susceptibility were genotyped, and haplotype associations between groups were assessed.
Results: Using the NCI-CTC scoring system, the patients were grouped according to adverse gastrointestinal reaction within 3 months of starting radiotherapy: a reaction grade =< 1, n = 106, and the reaction grade >= 2, n = 47. No association between any clinical factors and the adverse reactions was observed. Global haplotype association analysis (P < 0.05 and false discovery rate < 0.05) indicated that estimated haplotypes in the 8 loci were associated with risk. We revealed 4 haplotypes significantly related with adverse reaction risks.
Conclusions: Individual radiosensitivity may be partly determined by these haplotypes in multiple loci. Our data could be the evidence to lead a better understanding of the mechanisms in individual radiation sensitivity.
子宮頚癌放射線治療の副作用発症リスクと関連するハプロタイプの同定
