量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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The 3-year project of basic research aimed at the development of the porphyrin-induced DDS-type cancer therapy is ending before demonstrating its fruits with the
microPET due to unforeseen delay in its installation. Nevertheless, during this final year we continued the following programs for clinical applications.
(1) Installation of the microPET has been completed, and now it is ready for basic studies in vitro on porphyrin accumulation in cancer, and to test the new cancer-imaging merthod using the 52Fe-labelled porphyrin.
(2) While a microPET facility is being installed at NIRS, we have accumulated experimental data that confirmed our hypothetical interpretations on the behavior of porphyrin in cancer at Tsukuba University.
(3) Porphyrin compounds for cancer imaging have been developed at Tokyo University of Science. The technicalfeasibility of fabricating Fe-porphyrin, and Mn-porphyrin
for the PET and for the enhanced MRI imaging were established. Now we are ready to test the new imaging methods applying to animals, before clinical applications.
ポルフィリン誘導DDS型癌医療のための基礎研究
